M
Malcolm F. G. Stevens
Researcher at University of Nottingham
Publications - 316
Citations - 13044
Malcolm F. G. Stevens is an academic researcher from University of Nottingham. The author has contributed to research in topics: Temozolomide & Benzothiazole. The author has an hindex of 57, co-authored 315 publications receiving 12291 citations. Previous affiliations of Malcolm F. G. Stevens include Keele University & Hauptman-Woodward Medical Research Institute.
Papers
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Journal ArticleDOI
Cyclisation reactions of azolylhydrazones derived from ethyl cyanoacetate and malononitrile. Formation of azolo[5,1-c][1,2,4]triazines
TL;DR: In this article, it was shown that the azole ring is more stable than the 1,2,4-triazine ring on electron impact, and that the triazolotriazines were identical with known derivatives and which served to establish the [5,1c] geometry of ring fusion.
Journal ArticleDOI
Antitumour benzothiazoles. Part 2. Formation of 2,2′-diaminobiphenyls from the decomposition of 2-(4-azidophenyl)benzazoles in trifluoromethanesulfonic acid
TL;DR: In this paper, 2,2′-Diaminobiphenyls are formed by initial C-C coupling interactions between the π-carbocations and undecomposed 2-(4-azidophenyl)benzazoles and not by benzidine-type rearrangements as originally proposed.
Journal ArticleDOI
Antitumour polycyclic acridines. Part 3.1 A two-step conversion of 9-azidoacridine to 7H-pyrido[4,3,2-kl]acridines by Graebe–Ullmann thermolysis of substituted 9-(1,2,3-triazol-1-yl)acridines
TL;DR: In this article, the Graebe-Ullmann fragmentation of the triazolylacridines was monitored by differential scanning calorimetry and preparative thermolytic conversion to 2 or 3-substituted 7H-pyrido[4,3,2-kl]acridine was performed in hot diphenyl ether.
Journal ArticleDOI
Antitumour imidazotetrazines. Part 12. Reactions of mitozolomide and its 3-alkyl congeners with oxygen, nitrogen, halogen, and carbon nucleophiles
TL;DR: The 3-methyl and 3-ethyl analogues of mitozolomide decompose in alcohols to form 2-azahypoxanthine and 5-amino-1-alkoxycarbonylimidazole-4-carboxamides as discussed by the authors.
Patent
Substituted 2-arylbenzazole compounds and their use as antitumour agents
TL;DR: Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, -CH2- or -CH=CH-, exhibit selective antiproliferative activity in respect of mammalian tumour cells.