M
Man Seong Park
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 47
Citations - 1854
Man Seong Park is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 11, co-authored 11 publications receiving 1506 citations. Previous affiliations of Man Seong Park include Hallym University.
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Journal ArticleDOI
Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins.
Man Seong Park,Megan L. Shaw,Jorge L. Muñoz-Jordán,Jérôme Cros,Takaaki Nakaya,Nicole M. Bouvier,Peter Palese,Adolfo García-Sastre,Christopher F. Basler +8 more
TL;DR: It is shown that expression of the NDV V protein or the Nipah virus V, W, or C proteins rescues NDV-GFP replication in the face of the transfection-induced IFN response, and that the NDVs could be used to screen proteins expressed from plasmids for the ability to counteract the host cellIFN response.
Journal ArticleDOI
Influenza Virus Evades Innate and Adaptive Immunity via the NS1 Protein
Ana Fernandez-Sesma,Svetlana Marukian,Barbara J. Ebersole,Dorothy Kaminski,Man Seong Park,Tony Yuen,Stuart C. Sealfon,Adolfo García-Sastre,Thomas M. Moran +8 more
TL;DR: The results indicate that the influenza A virus NS1 protein is a bifunctional viral immunosuppressor which inhibits innate immunity by preventing type I IFN release and inhibits adaptive immunity by attenuating human DC maturation and the capacity of DCs to induce T-cell responses.
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Engineered viral vaccine constructs with dual specificity: avian influenza and Newcastle disease.
TL;DR: It is proposed that chimeric constructs should be developed for convenient, affordable, and effective vaccination against avian influenza and Newcastle disease in chickens and other poultry.
Journal ArticleDOI
Newcastle Disease Virus V Protein Is a Determinant of Host Range Restriction
TL;DR: The host range of NDV is limited by the ability of its V protein to efficiently prevent innate host defenses, such as the IFN response and apoptosis, which is species specific.
Journal ArticleDOI
Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus.
Adam Vigil,Man Seong Park,Osvaldo Martinez,Mark A. Chua,Sa Xiao,Jérôme Cros,Luis Martinez-Sobrido,Savio L. C. Woo,Adolfo García-Sastre +8 more
TL;DR: The data show the use of reverse genetics to develop enhanced recombinant NDV vectors as effective therapeutic agents for cancer treatment, with a majority of the mice undergoing complete and long-lasting remission.