M
Megan L. Shaw
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 46
Citations - 4887
Megan L. Shaw is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 25, co-authored 43 publications receiving 4219 citations. Previous affiliations of Megan L. Shaw include University of Glasgow & University of the Western Cape.
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Journal ArticleDOI
Human host factors required for influenza virus replication
Renate König,Silke Stertz,Yingyao Zhou,Atsushi Inoue,H.-Heinrich Hoffmann,Suchita Bhattacharyya,Judith G. Alamares,Donna M. Tscherne,Mila Brum Ortigoza,Yuhong Liang,Qinshan Gao,Shane E. Andrews,Sourav Bandyopadhyay,Paul D. De Jesus,Buu P. Tu,Lars Pache,Crystal Shih,Anthony P. Orth,Ghislain M. C. Bonamy,Loren Miraglia,Trey Ideker,Adolfo García-Sastre,John A. T. Young,Peter Palese,Megan L. Shaw,Sumit K. Chanda +25 more
TL;DR: This work uses an integrative systems approach, based on genome-wide RNA interference screening, to identify 295 cellular cofactors required for early-stage influenza virus replication, and identifies those involved in kinase-regulated signalling, ubiquitination and phosphatase activity as the most highly enriched.
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Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
Shashank Tripathi,Marie O. Pohl,Yingyao Zhou,Ariel Rodriguez-Frandsen,Guojun Wang,David A. Stein,Hong M. Moulton,Paul DeJesus,Jianwei Che,Lubbertus C. F. Mulder,Emilio Yángüez,Dario Andenmatten,Lars Pache,Balaji Manicassamy,Randy A. Albrecht,Maria G. Gonzalez,Quy T. Nguyen,Abraham L. Brass,Stephen J. Elledge,Stephen J. Elledge,Michael A. White,Sagi Shapira,Nir Hacohen,Alexander Karlas,Thomas F. Meyer,Michael Shales,Andre Gatorano,Jeffrey R. Johnson,Gwen Jang,Tasha L. Johnson,Erik Verschueren,Doug Sanders,Nevan J. Krogan,Megan L. Shaw,Renate König,Renate König,Silke Stertz,Adolfo García-Sastre,Sumit K. Chanda +38 more
TL;DR: A meta-analysis of data from eight published RNAi screens and integrated with three protein interaction datasets revealed a functionally validated biochemical landscape of the influenza-host interface, which illuminates a viral-host network of high-confidence human proteins that are essential for influenza A virus replication.
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Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation
St. Patrick Reid,Lawrence W. Leung,Amy L. Hartman,Osvaldo Martinez,Megan L. Shaw,Caroline Carbonnelle,Viktor E. Volchkov,Stuart T. Nichol,Christopher F. Basler +8 more
TL;DR: It is demonstrated that the EBOV VP24 protein functions as an inhibitor ofIFN-α/β and IFN-γ signaling, and is likely to be an important virulence determinant that allows E BOV to evade the antiviral effects of IFNs.
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Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins.
Man Seong Park,Megan L. Shaw,Jorge L. Muñoz-Jordán,Jérôme Cros,Takaaki Nakaya,Nicole M. Bouvier,Peter Palese,Adolfo García-Sastre,Christopher F. Basler +8 more
TL;DR: It is shown that expression of the NDV V protein or the Nipah virus V, W, or C proteins rescues NDV-GFP replication in the face of the transfection-induced IFN response, and that the NDVs could be used to screen proteins expressed from plasmids for the ability to counteract the host cellIFN response.
Journal ArticleDOI
Cellular proteins in influenza virus particles.
TL;DR: The identification of cellular constituents of influenza virions has important implications for understanding the interactions of influenza virus with its host and brings us a step closer to defining the cellular requirements for influenza virus replication.