M
Manasi Benurwar
Researcher at Katholieke Universiteit Leuven
Publications - 4
Citations - 678
Manasi Benurwar is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Gamma secretase & Presenilin. The author has an hindex of 4, co-authored 4 publications receiving 599 citations.
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Journal ArticleDOI
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
Lucía Chávez-Gutiérrez,Leen Bammens,Iryna Benilova,Annelies Vandersteen,Annelies Vandersteen,Manasi Benurwar,Marianne Borgers,Sam Lismont,Lujia Zhou,Simon Van Cleynenbreugel,Hermann Esselmann,Jens Wiltfang,Lutgarde Serneels,Eric Karran,Harrie J.M. Gijsen,Joost Schymkowitz,Frederic Rousseau,Frederic Rousseau,Kerensa Broersen,Kerensa Broersen,Bart De Strooper +20 more
TL;DR: Overall, this work provides a coherent explanation for the effect of different FAD mutations, demonstrating the importance of qualitative rather than quantitative changes in the Aβ products, and suggest fundamental improvements for current drug development efforts.
Journal ArticleDOI
Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
Maria Szaruga,Sarah Veugelen,Manasi Benurwar,Sam Lismont,Diego Sepulveda-Falla,Alberto Lleó,Natalie S. Ryan,Tammaryn Lashley,Nick C. Fox,Shigeo Murayama,Harrie J.M. Gijsen,Bart De Strooper,Bart De Strooper,Lucía Chávez-Gutiérrez +13 more
TL;DR: Analysis of patients’ brains shows that mutations in the catalytic subunit of the γ-secretase complex, Presenilin, cause familial Alzheimer’s disease but these mutations do not result in loss of enzymatic function but in qualitative changes in Aβ product profiles.
Journal ArticleDOI
Signature Amyloid β Profiles Are Produced by Different γ-Secretase Complexes
Hermien Acx,Lucía Chávez-Gutiérrez,Lutgarde Serneels,Sam Lismont,Manasi Benurwar,Nadav Elad,Bart De Strooper,Bart De Strooper +7 more
TL;DR: It is found that the nature of the catalytic subunit in the complex affects both activities, and each γ-secretase complex produces a characteristic Aβ signature, which could be used to advance drug development in AD and other disorders.