M
Marianne Borgers
Researcher at Katholieke Universiteit Leuven
Publications - 4
Citations - 466
Marianne Borgers is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Epitope & Tau protein. The author has an hindex of 2, co-authored 4 publications receiving 420 citations. Previous affiliations of Marianne Borgers include Johnson & Johnson.
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Journal ArticleDOI
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
Lucía Chávez-Gutiérrez,Leen Bammens,Iryna Benilova,Annelies Vandersteen,Annelies Vandersteen,Manasi Benurwar,Marianne Borgers,Sam Lismont,Lujia Zhou,Simon Van Cleynenbreugel,Hermann Esselmann,Jens Wiltfang,Lutgarde Serneels,Eric Karran,Harrie J.M. Gijsen,Joost Schymkowitz,Frederic Rousseau,Frederic Rousseau,Kerensa Broersen,Kerensa Broersen,Bart De Strooper +20 more
TL;DR: Overall, this work provides a coherent explanation for the effect of different FAD mutations, demonstrating the importance of qualitative rather than quantitative changes in the Aβ products, and suggest fundamental improvements for current drug development efforts.
Journal ArticleDOI
A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities
Adrian Constantin Apetri,Rosa Crespo,Jarek Juraszek,Gabriel Pascual,Roosmarijn Janson,Xueyong Zhu,Heng Zhang,Elissa Keogh,Trevin Holland,Jay Wadia,Jay Wadia,Hanneke Verveen,Berdien Siregar,Michael Mrosek,Renske Taggenbrock,Jeroen van Ameijde,Hanna Inganäs,Margot van Winsen,Martin H. Koldijk,David Zuijdgeest,Marianne Borgers,Koen Dockx,Esther J. M. Stoop,Wenli Yu,Els C. M. Brinkman-Van der Linden,Kimberley Ummenthum,Kristof Van Kolen,Marc Mercken,Stefan Steinbacher,Donata de Marco,Jeroen J.M. Hoozemans,Ian A. Wilson,Wouter Koudstaal,Jaap Goudsmit,Jaap Goudsmit +34 more
TL;DR: Crystal structures revealed that the combination of VH5–51 and VL4–1 recognizes a common Pro-Xn-Lys motif driven by germline-encoded hotspot interactions while the specificity and thereby functionality of the antibodies are defined by the CDR3 regions.
Posted ContentDOI
Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities
Adrian Constantin Apetri,Rosa Crespo,Jarek Juraszek,Gabriel Pascual,Roosmarijn Janson,Xueyong Zhu,Elissa Keogh,Heng Zhang,Trevin Holland,Jay Wadia,Hanneke Verveen,Berdien Siregar,Michael Mrosek,Renske Taggenbrock,Jeroen van Ameijde,Hanna Inganäs,Margot van Winsen,Martin H. Koldijk,David Zuijdgeest,Marianne Borgers,Koen Dockx,Esther J. M. Stoop,Wenli Yu,Els C. M. Brinkman-Van der Linden,Kimberley Ummenthum,Kristof Van Kolen,Marc Mercken,Stefan Steinbacher,Donata de Marco,Jeroen J.M. Hoozemans,Ian A. Wilson,Wouter Koudstaal,Jaap Goudsmit +32 more
TL;DR: Crystal structures revealed that the combination of VH5-51 and VL4-1 recognizes a common Pro-Xn-Lys motif driven by germline-encoded hotspot interactions while the specificity and thereby functionality of the antibodies are defined by the CDR3 regions.
Journal Article
Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities
Adrian Constantin Apetri,Rosa Crespo,Jarek Juraszek,Gabriel Pascual,Roosmarijn Janson,Xueyong Zhu,Elissa Keogh,Heng Zhang,Trevin Holland,Jay Wadia,Hanneke Verveen,Berdien Siregar,Michael Mrosek,Renske Taggenbrock,Jeroen van Ameijde,Hanna Inganäs,Margot van Winsen,Martin H. Koldijk,David Zuijdgeest,Marianne Borgers,Koen Dockx,Esther J. M. Stoop,Wenli Yu,Els C. M. Brinkman-Van der Linden,Kimberley Ummenthum,Kristof Van Kolen,Marc Mercken,Stefan Steinbacher,Donata de Marco,Jeroen J.M. Hoozemans,Ian A. Wilson,Wouter Koudstaal,Jaap Goudsmit +32 more
TL;DR: In this paper, the aggregation motif in the R3 repeat domain and blocks the aggregation of tau into paired helical filaments (PHFs) by sequestering monomeric tau.