M
Manfred F. Rajewsky
Researcher at University of Duisburg-Essen
Publications - 133
Citations - 3874
Manfred F. Rajewsky is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: DNA & DNA repair. The author has an hindex of 35, co-authored 133 publications receiving 3818 citations. Previous affiliations of Manfred F. Rajewsky include Max Planck Society & Heidelberg University.
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Journal ArticleDOI
Anticancer Agents, 15. Squaric Acid Diethyl Ester: A New Coupling Reagent for the Formation of Drug Biopolymer Conjugates. Synthesis of Squaric Acid Ester Amides and Diamides
Lutz F. Tietze,Michael Arlt,Matthias Beller,Karl‐Heinz Gl üsenkamp,Eckhard Jähde,Manfred F. Rajewsky +5 more
TL;DR: In this article, the reaction of squaric acid diethyl esters with a slight excess of a primary or secondary amine 2 in ethanol, dichloromethane or aqueous buffer (pH 7) at 20°C for 03-12 h was investigated.
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Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nervous system by ethylnitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues
R. Goth,Manfred F. Rajewsky +1 more
TL;DR: It was, therefore, of interest to find a significant difference between brain and other tissues with regard to the elimination rate from DNA of O6-EG, and the capacity of the target cell to eliminate O 6-EG from its DNA may be an important factor in determining the probability of neoplastic transformation.
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06-Methyldeoxyguanosine in oesophageal dna among individuals at high risk of oesophageal cancer
D Umbenhauer,D Umbenhauer,Christopher P. Wild,Ruggero Montesano,Roy Saffhill,John M Boyle,Nam Ho Huh,U Kirstein,Jürgen Thomale,Manfred F. Rajewsky,S.H. Lu +10 more
TL;DR: A radioimmunoassay using monoclonal antibodies against 06‐medGuo and 06‐etdGuo enabled the presence of these DNA adducts to be detected in human tissues and appear promising in assessing the role of alkylating agents, e.g. nitrosamines, in the aetiology of human cancer.
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pH in human tumour xenografts: effect of intravenous administration of glucose.
TL;DR: In this paper, 30 human tumour xenografts were analysed with the use of H+ ion-sensitive semi-microelectrodes prior to and following stimulation of tumour cell glycolysis by infusion of glucose.
Journal Article
Tumor-selective Modification of Cellular Microenvironment in Vivo: Effect of Glucose Infusion on the pH in Normal and Malignant Rat Tissues
TL;DR: In hyperglycemic hosts, an increased retention of acidic metabolites in the tumor tissue with decreasing vascular density was reflected by a tumor size (age)-dependent pH reduction and a higher degree of intratumoral pH variation.