Manfred Kraus

TL;DR: Three points at which c-Myb activity is required for normal T cell differentiation are identified: transition through the double-negative 3 stage, survival of preselection CD4+CD8+ thymocytes, and differentiation of CD4Thymocytes.

TL;DR: It is shown that interruption of basal IgM signaling in immature B cells, either by the inducible deletion of surface Ig via Cre-mediated excision or by incubating cells with the tyrosine kinase inhibitor herbimycin A or the phosphatidylinositol 3-kinase inhibitor wortmannin led to a striking “back-differentiation” of cells to an earlier stage in B cell development.

TL;DR: A pathway-based phosphoprofiling approach to identify and quantify clinically relevant, drug-specific biomarkers for phosphatidylinositol 3-kinase (PI3K) pathway inhibitors that target AKT, phosphoinositide-dependent kinase 1 (PDK1), and PI3K–mammalian target of rapamycin (mTOR) is reported.

TL;DR: The results suggest that the γ1 chain can exert a unique signaling function that can partially replace that of the Igα/β heterodimer in B cell maintenance and may contribute to memory B cell physiology.

TL;DR: In this article, the authors demonstrate that both development and maintenance of the splenic marginal zone is highly dependent on the presence of B cells and that B cells are not only important for the development, but also for maintenance, of the marginal zone.