R
Reina E. Mebius
Researcher at VU University Amsterdam
Publications - 130
Citations - 16267
Reina E. Mebius is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Lymph node stromal cell & Lymphatic system. The author has an hindex of 55, co-authored 122 publications receiving 14119 citations. Previous affiliations of Reina E. Mebius include VU University Medical Center.
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Journal ArticleDOI
Innate lymphoid cells--a proposal for uniform nomenclature.
Hergen Spits,David Artis,Marco Colonna,Andreas Diefenbach,James P. Di Santo,Gérard Eberl,Shigeo Koyasu,Richard M. Locksley,Andrew N.J. McKenzie,Reina E. Mebius,Fiona Powrie,Eric Vivier,Eric Vivier +12 more
TL;DR: It is proposed that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function.
Journal ArticleDOI
Structure and function of the spleen.
Reina E. Mebius,Georg Kraal +1 more
TL;DR: The spleen enables it to remove older erythrocytes from the circulation and leads to the efficient removal of blood-borne microorganisms and cellular debris, which makes it the most important organ for antibacterial and antifungal immune reactivity.
Journal ArticleDOI
Innate Lymphoid Cells: 10 Years On.
Eric Vivier,David Artis,Marco Colonna,Andreas Diefenbach,James P. Di Santo,James P. Di Santo,Gérard Eberl,Gérard Eberl,Shigeo Koyasu,Richard M. Locksley,Andrew N. J. McKenzie,Reina E. Mebius,Fiona Powrie,Hergen Spits +13 more
TL;DR: The advances in ILC biology over the past decade are distill the advances to refine the nomenclature of ILCs and highlight the importance of I LCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration.
Journal ArticleDOI
Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development
Zuoming Sun,Derya Unutmaz,Yong-Rui Zou,Mary Jean Sunshine,Alessandra Pierani,Susan Brenner-Morton,Reina E. Mebius,Dan R. Littman +7 more
TL;DR: It is shown that mice lacking the orphan nuclear hormone receptor RORgamma lose thymic expression of the anti-apoptotic factor Bcl-xL, which regulates the survival of CD4+8+ thymocytes and may control the temporal window during which thymocyte can undergo positive selection.
Journal ArticleDOI
Organogenesis of lymphoid tissues.
TL;DR: An integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3−CD4+CD45+ 'inducer' cells and VCAM1+ICAM1- stromal 'organizer' cells is presented.