Journal ArticleDOI
Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice.
Syed Hamid Ali,Rajaram Mohanrao Madhana,Athira K,Eshvendar Reddy Kasala,Lakshmi Narendra Bodduluru,Sathish Pitta,Jalandhar Reddy Mahareddy,Mangala Lahkar +7 more
TLDR
The results suggest that resveratrol produces an antidepressant-like effect in CORT-induced depression in mice, which is possibly mediated by rectifying the stress-based hypothalamic-pituitary-adrenal (HPA) axis dysfunction paradigm and upregulation of hippocampal BDNF levels.About:
This article is published in Steroids.The article was published on 2015-09-01. It has received 116 citations till now. The article focuses on the topics: Resveratrol & Corticosterone.read more
Citations
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Journal ArticleDOI
Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
Burak Ibrahim Arioz,Bora Tastan,Emre Tarakcioglu,Kemal Ugur Tufekci,Melis Olcum,Nevin Ersoy,Alper Bagriyanik,Kursad Genc,Sermin Genc +8 more
TL;DR: Melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition ofNLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1 β (IL-1β) maturation and secretion.
Journal ArticleDOI
The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder.
Pawan Kumar Maurya,Cristiano Noto,Lucas B. Rizzo,Adiel C. Rios,Sandra Odebrecht Vargas Nunes,Décio Sabbatini Barbosa,Sumit Sethi,Maiara Zeni,Rodrigo B. Mansur,Michael Maes,Elisa Brietzke +10 more
TL;DR: Since, aging and MDD share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising.
Journal ArticleDOI
Cortisol and Major Depressive Disorder-Translating Findings From Humans to Animal Models and Back.
TL;DR: It is argued that the absolute level of cortisol is unreliable for predicting the efficacy of antidepressant treatment and it is proposed that future preclinical models should reliably produce exaggerated HPA axis responses to acute or chronic stress a priori, which may, or may not, alter baseline cortisol levels.
Journal ArticleDOI
Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis
Liang Liu,Qin Zhang,Yulong Cai,Dayu Sun,Xie He,Lian Wang,Dan Yu,Xin Li,Xiao-Yi Xiong,Haiwei Xu,Qing-Wu Yang,Xiaotang Fan +11 more
TL;DR: Data indicated that RSV-induced Sirt1 activation counteracts LPS-induced depression-like behaviors via a neurogenic mechanism, and a new model to understand the role of RSV in treating depression may result from these findings.
Journal ArticleDOI
Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms.
TL;DR: Based on these findings, resveratrol may be deemed an effective treatment for depression in animal models at doses between 10–80 mg/kg/day, although higher doses had the most significant effects.
References
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Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
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The tail suspension test: A new method for screening antidepressants in mice
TL;DR: A novel test procedure for antidepressants was designed in which a mouse is suspended by the tail from a lever, the movements of the animal being recorded, and the test can separate the locomotor stimulant doses from antidepressant doses.
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New insights into BDNF function in depression and anxiety
TL;DR: BDNF may be a target of antidepressants, but not the sole mediator of depression or anxiety, and as the precursor proBDNF and the mature protein mBDNF can elicit opposite effects on cellular functions, the impact of proBD NF and its cleavage on mood should be considered.
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Plant foods and herbal sources of resveratrol.
TL;DR: For people who do not consume alcohol, Itadori tea may be a suitable substitute for red wine and there is also a need for more information on the absorption and in vivo biomedical actions of free and conjugated resveratrol.
Journal ArticleDOI
The stress system in the human brain in depression and neurodegeneration.
TL;DR: It is hypothesized that particularly a subgroup of CRH neurons that projects into the brain is activated in depression and induces the symptoms of this disorder, which is a basis for the higher prevalence of mood disorders in women as compared to men.