Showing papers in "Steroids in 2015"

TL;DR: The results suggest that testosterone treatment probably improves BMD, but the results are less conclusive in older versus younger men, and testosterone treatment of men with unequivocally low serum testosterone will increase volumetric BMD of the spine.

TL;DR: Current evidence is summarized and key areas to be addressed in future epidemiologic studies of endogenous estrogens and the risk of breast, endometrial, and ovarian cancers are identified.

TL;DR: The steroidogenesis, hormone receptors, and function of the steroid hormones are reasonably well understood when summarizing the available data of all teleost species analyzed to date, however, on the level of a single species or a certain fish-specific aspect of physiology, further research is needed.

TL;DR: Skin is a neuroendocrine organ endowed with steroid/secosteroidogenic activities and establishment of which intermediates are produced in the epidermis in vivo and whether they circulate on the systemic level represent a future research challenge.

TL;DR: This review article focuses on recent developments regarding the origin and function of Leydig cells, the regulation of their differentiation by signaling molecules, hormones, and structural changes, the signaling pathways, kinases, and transcription factors involved in their differentiation and in mediating LH-responsiveness, as well as the fine-tuning mechanisms that ensure adequate production steroid hormones.

TL;DR: A role for estradiol metabolism as one of the components in the development of experimental breast cancer is supported, based on the hypothesis that both receptor-mediated and genotoxic pathways contribute to breast cancer.

TL;DR: The skin irritating principle from Thapsia garganica was isolated, named thapsigargin and the structure elucidated and prodrugs were created, which selectively affect prostate cancer cells or neovascular tissue in tumors.

TL;DR: The results suggest that resveratrol produces an antidepressant-like effect in CORT-induced depression in mice, which is possibly mediated by rectifying the stress-based hypothalamic-pituitary-adrenal (HPA) axis dysfunction paradigm and upregulation of hippocampal BDNF levels.

TL;DR: Observations support the notion that targeting the estrogen/estrone metabolism pathway may be another way to reduce breast cancer risk.

TL;DR: In 158N murine oligodendrocytes, the concept that oxiapoptophagy, which can be inhibited by VitE and DHA, could be a particular mode of cell death elicited by cytotoxic oxysterols is supported.

TL;DR: FA loaded NLCs could be a potential system for psoriasis treatment but to create clinical value of the present system further studies are needed in clinically relevant models.

TL;DR: A novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed to measure concurrently all 15 estrogens and estrogen metabolites in human serum and urine, as unconjugated and total concentrations, and demonstrated that enhanced 2-hydroxylation of parent estrogens (estrone+estradiol) is associated with reduced risk of postmenopausal breast cancer.

TL;DR: The associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method are described, using data from a collaborative pooled analysis of 18 prospective studies.

TL;DR: The evidence indicating the presence of the entire steroidogenic apparatus in adipose tissue is summarized and the potential roles of local steroid products in modulating adipOSE tissue activity and other metabolic parameters are discussed.

TL;DR: In this paper, the authors measured the difference in the oxysterol content of blood plasma in the jugular vein and in a forearm vein by mass spectrometry (MS) and were able to determine the flux of more than 20 cholesterol metabolites between brain and the circulation.

TL;DR: This review will discuss CRPC in general with a specific focus on Abiraterone acetate (AA) and novel CYP17A1 inhibitors, which underlies one of the most recent advances in the treatment of CRPC.

TL;DR: The anti-inflammatory and anti-ulcer evaluations of the newly synthesized products showed that 23f showed the maximum antiulcer activity and toxicity of the most active compounds showed non-toxicity against the tested organisms.

TL;DR: Possible E2 neuroprotection is commented as a group of experimental evidence on excitotoxic and oxidative retinal paradigms, and models of retinal neurodegenerative diseases, such as glaucoma, diabetic retinopathy and AMD.

TL;DR: A new validated gas chromatography selected reaction monitoring - tandem mass spectrometry assay (GC-MS/MS) for the simultaneous quantification of ten endogenous steroids including progesterone (PROG), dehydroepiandrosterone (DHEA), androstenediol (5-diol),androstenedione (4-dione), testosterone (T), dihydrotestosterone (DHT), androsterone

TL;DR: Evidence is provided that BS possess similar types of activity also beyond plant kingdom at concentrations comparable with those for plants, looking at steroids from a new point of view: how common are the mechanisms of steroid bioregulation in different types of organisms.

TL;DR: An ultrasensitive stable isotope dilution liquid chromatography-tandem mass spectrometry method was developed and validated for multiplexed quantitative analysis of six unconjugated and conjugated estrogens in human serum, suggesting that the level of total 4-MeO-E2 could be a potential biomarker for breast cancer cases.

TL;DR: The study suggests that 5HT3 antagonist; 4i may be implicated as pharmacological intervention targeting depressive-like anomaly associated with HPA-axis dysregulation, which may plausibly demonstrate one of the key mechanisms for antidepressant-like effects of the compounds.

TL;DR: The metabolic processes performed by syncytiotrophoblast mitochondria associated with placental steroidogenesis are described, including how this steroid hormone precursor reaches the mitochondria, and its transformation into progesterone are reviewed.

TL;DR: The LC-MS/MS method using triple stage quadrupole-mass spectrometer was developed and enables simultaneous quantification of steroids important for the estimation of 11β-HSD activity in human plasma and CSF, helpful in better understanding various degenerative diseases development and progression.

TL;DR: Research findings on non-genomic effects of NR4A1 in normal and cancer cells are summarized to indicate a significant role of NR3A2 in the process of autophagy.

TL;DR: A random serum progesterone level ⩾5ng/ml confirms ovulation, which may be of use for clinicians wanting to confirm that ovulation has occurred.

TL;DR: Observations to date supporting the concept that neuroactive steroids are synthesized in the peripheral nervous system, regulate the physiology of peripheral nerves and exert notable neuroprotective actions are summarized.

TL;DR: High levels of androstenedione and testosterone and significant estrone and estradiol levels in breast adipocytes from postmenopausal breast cancer patients are consistent with an obesity-inflammation-aromatase axis occurring locally in breast tissue.

TL;DR: A new chemical derivatization reagent was applied modifying phenolic steroids to form 1-methylimidazole-2-sulfonyl adducts, which significantly improves the sensitivity 2-100 fold by full scan MS and targeted selected ion monitoring MS over other derivatized methods including, dansyl, picolinoyl, and pyridine-3-solfonyl products.

TL;DR: The data provide the first evidence that obesity and metabolic syndrome are associated with major, gender-specific, changes in circulating oxysterols and fatty acids, and that oxysterol may contribute to the epidemic diseases associated with obesity and metabolism syndrome in female.