M
Mani Ganeshpandian
Researcher at SRM University
Publications - 19
Citations - 764
Mani Ganeshpandian is an academic researcher from SRM University. The author has contributed to research in topics: Ligand & Base pair. The author has an hindex of 11, co-authored 16 publications receiving 591 citations. Previous affiliations of Mani Ganeshpandian include Bharathidasan University & Central University of Tamil Nadu.
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Journal ArticleDOI
New ruthenium(II) arene complexes of anthracenyl-appended diazacycloalkanes: effect of ligand intercalation and hydrophobicity on DNA and protein binding and cleavage and cytotoxicity
Mani Ganeshpandian,Rangasamy Loganathan,Eringathodi Suresh,Anvarbatcha Riyasdeen,Mohammad Abdulkadher Akbarsha,Mohammad Abdulkadher Akbarsha,Mallayan Palaniandavar +6 more
TL;DR: The anticancer activity of complexes has been studied by employing various biochemical methods involving different staining agents, AO/EB and Hoechst 33258, which reveal that complexes 1-4 establish a specific mode of cell death in MCF 7 breast cancer cells.
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Interaction of mixed ligand copper(II) complexes with CT DNA and BSA: Effect of primary ligand hydrophobicity on DNA and protein binding and cleavage and anticancer activities
Mani Ganeshpandian,Rangasamy Loganathan,Sethu Ramakrishnan,Anvarbatcha Riyasdeen,Mohamad Abdulkadhar Akbarsha,Mohamad Abdulkadhar Akbarsha,Mallayan Palaniandavar,Mallayan Palaniandavar +7 more
TL;DR: The complex 3, which strongly binds to both DNA and protein and performs both DNA cleavage and protein cleavage, exhibits a higher cytotoxicity than the other complexes due to enhanced hydrophobicity of both pmdt and the diimine co-ligand.
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Mixed ligand copper(II) complexes of 1,10-phenanthroline with tridentate phenolate/pyridyl/(benz)imidazolyl Schiff base ligands: covalent vs non-covalent DNA binding, DNA cleavage and cytotoxicity.
Chandrasekaran Rajarajeswari,Mani Ganeshpandian,Mallayan Palaniandavar,Anvarbatcha Riyasdeen,Mohammad Abdulkadher Akbarsha +4 more
TL;DR: UV-Vis and fluorescence spectral studies reveal that the complexes 1-6 bind non-covalently to calf thymus DNA more strongly than the corresponding covalently bound chlorido complexes[Cu(2NO)Cl] 1a-2a and [Cu(3N)Cl2] 3a-6a.
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Mixed ligand copper(II) complexes of 2,9-dimethyl-1,10-phenanthroline: tridentate 3N primary ligands determine DNA binding and cleavage and cytotoxicity.
Mani Ganeshpandian,Sethu Ramakrishnan,Mallayan Palaniandavar,Eringathodi Suresh,Anvarbatcha Riyasdeen,Mohammad Abdulkadher Akbarsha +5 more
TL;DR: Flow cytometry analysis reveals that 1 mediates the arrest of S and G2/M phases in the cell cycle progression at 24h harvesting time, which progresses into apoptosis, and hoechst 33258 staining studies indicate the higher potency of 1 to induce apoptosis.
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DNA and protein binding, double-strand DNA cleavage and cytotoxicity of mixed ligand copper(II) complexes of the antibacterial drug nalidixic acid.
Rangasamy Loganathan,Mani Ganeshpandian,Nattamai Bhuvanesh,Mallayan Palaniandavar,Amsaveni Muruganantham,Swapan K. Ghosh,Anvarbatcha Riyasdeen,Mohammad Abdulkader Akbarsha +7 more
TL;DR: The water soluble mixed ligand complexes 1-4, where H(nal) is nalidixic acid and diimine is 2,2'-bipyridine, show cytotoxicity higher than 1 and 2 against human breast cancer cell lines (MCF-7) and the complex 4 induces apoptotic mode of cell death in cancer cells.