M
Mani Ramaswami
Researcher at Trinity College, Dublin
Publications - 116
Citations - 6728
Mani Ramaswami is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Synaptic vesicle & Dynamin. The author has an hindex of 44, co-authored 108 publications receiving 6136 citations. Previous affiliations of Mani Ramaswami include California Institute of Technology & Tata Institute of Fundamental Research.
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Journal ArticleDOI
Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders
TL;DR: Observations suggest that understanding and modulating RNP assembly or clearance may be effective approaches to developing therapies for degenerative diseases.
Journal ArticleDOI
Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies.
Scott A. Barbee,Patricia S. Estes,Anne Marie J. Cziko,Jens Hillebrand,Rene Luedeman,Jeff Coller,Nicholas E. Johnson,Iris C. Howlett,Cuiyun Geng,Ryu Ueda,Andrea H. Brand,Sarah F. Newbury,James E. Wilhelm,Richard B. Levine,Akira Nakamura,Roy Parker,Mani Ramaswami +16 more
TL;DR: It is shown that staufen- and FMRP-containing RNPs in Drosophila neurons contain proteins also present in somatic "P bodies," including the RNA-degradative enzymes Dcp1p and Xrn1p/Pacman and crucial components of miRNA (argonaute), NMD (Upf1p), and general translational repression pathways.
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The Organization of Extrinsic Neurons and Their Implications in the Functional Roles of the Mushroom Bodies in Drosophila melanogaster Meigen
Kei Ito,Kazumi Suzuki,Kazumi Suzuki,Patricia S. Estes,Mani Ramaswami,Daisuke Yamamoto,Nicholas J. Strausfeld +6 more
TL;DR: In this paper, a novel presynaptic reporter construct, UAS-neuronal synaptobrevin-green fluorescent protein (n-syb-GFP), was used to reveal the direction of information in the GAL4-labeled neurons.
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A genome-wide resource for the analysis of protein localisation in Drosophila.
Mihail Sarov,Christiane Barz,Helena Jambor,Marco Y. Hein,Christopher Schmied,Dana Suchold,Bettina Stender,Stephan Janosch,Vinay Vikas Kj,Krishnan Rt,Aishwarya Krishnamoorthy,Irene R. S. Ferreira,Radoslaw K. Ejsmont,Katja Finkl,Susanne Hasse,Philipp Kaempfer,Nicole Plewka,Elisabeth Vinis,Siegfried Schloissnig,Elisabeth Knust,Volker Hartenstein,Matthias Mann,Mani Ramaswami,K. VijayRaghavan,Pavel Tomancak,Frank Schnorrer +25 more
TL;DR: A genome-wide fosmid library of 10000 GFP-tagged clones, comprising tagged genes and most of their regulatory information that will boost systematic analysis of protein expression and localisation in various cellular and developmental contexts is presented.
Journal ArticleDOI
The Drosophila Easily Shocked Gene: A Mutation in a Phospholipid Synthetic Pathway Causes Seizure, Neuronal Failure, and Paralysis
TL;DR: Molecular cloning, germline transformation, and biochemical experiments show that eas mutants are defective in the gene for ethanolamine kinase, which is required for a pathway of phosphatidylethanolamine synthesis.