M
Manoj Kumar Barthwal
Researcher at Central Drug Research Institute
Publications - 108
Citations - 3151
Manoj Kumar Barthwal is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 28, co-authored 104 publications receiving 2595 citations. Previous affiliations of Manoj Kumar Barthwal include Academy of Scientific and Innovative Research & Council of Scientific and Industrial Research.
Papers
More filters
Journal ArticleDOI
Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition.
Ravi S. Keshari,Anupam Jyoti,Megha Dubey,Nikhil Kothari,Monica Kohli,Jaishri Bogra,Manoj Kumar Barthwal,Madhu Dikshit +7 more
TL;DR: Role of IL-1β, TNFα and IL-8 thus seems to be involved in the enhanced release of NETs in SIRS subjects.
Journal ArticleDOI
Reactive oxygen species‐induced activation of ERK and p38 MAPK mediates PMA‐induced NETs release from human neutrophils
TL;DR: It is demonstrated that ROS dependent activation of ERK and p38 MAPK, which mediated PMA induced NETs release from human neutrophils, was downstream to free radical generation.
Journal ArticleDOI
Macrophages: An elusive yet emerging therapeutic target of atherosclerosis
TL;DR: Deciphering the role of macrophages in regulating dyslipidemia and inflammation during atherosclerosis is important for developing them as therapeutic targets.
Journal ArticleDOI
Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation.
Satyananda Patel,Sachin Kumar,Anupam Jyoti,Bangalore Suresh Srinag,Ravi S. Keshari,Rohit Saluja,Anupam Verma,Kalyan Mitra,Manoj Kumar Barthwal,Hanumanthappa Krishnamurthy,Virendra K. Bajpai,Madhu Dikshit +11 more
TL;DR: It is demonstrated that NO by augmenting free radical formation in human neutrophils mediates NETs release, suggesting involvement of free radicals in NETs formation.
Journal ArticleDOI
Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
Nikhil Kothari,Ravi S. Keshari,Jaishri Bogra,Monica Kohli,Haider Abbas,Anita Malik,Madhu Dikshit,Manoj Kumar Barthwal +7 more
TL;DR: Results show that neutrophil activation occurring during inflammation and sepsis could be detected by plasma MPO concentration, and these concentrations may be a marker of the neutrophils proliferation and severity of inflammation.