V
Vishal Singh
Researcher at Pennsylvania State University
Publications - 67
Citations - 2407
Vishal Singh is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Inflammation & Gut flora. The author has an hindex of 22, co-authored 57 publications receiving 1735 citations. Previous affiliations of Vishal Singh include Penn State Cancer Institute & University of Toledo.
Papers
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Journal ArticleDOI
Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health.
Jun Zou,Benoit Chassaing,Vishal Singh,Michael A. Pellizzon,Matthew R. Ricci,Michael D. Fythe,Matam Vijay Kumar,Andrew T. Gewirtz +7 more
TL;DR: F fermentable fiber protects against metabolic syndrome by nourishing microbiota to restore IL-22-mediated enterocyte function, and is markedly protected against high-fat diet (HFD)-induced metabolic syndrome.
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Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.
Vishal Singh,Beng San Yeoh,Benoit Chassaing,Xia Xiao,Piu Saha,Rodrigo Aguilera Olvera,John D. Lapek,Limin Zhang,Wei Bei Wang,Sijie Hao,Michael D. Flythe,David Gonzalez,Patrice D. Cani,Jose R. Conejo-Garcia,Na Xiong,Mary J. Kennett,Bina Joe,Andrew D. Patterson,Andrew T. Gewirtz,Matam Vijay-Kumar +19 more
TL;DR: Enrichment of foods with fermentable fiber should be approached with great caution as it may increase risk of HCC, and pharmacologic inhibition of fermentation or depletion of fermenting bacteria markedly reduced intestinal SCFA and prevented HCC.
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Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation
Vishal Singh,Beng San Yeoh,Rachel E Walker,Xia Xiao,Piu Saha,Rachel M. Golonka,Jingwei Cai,Alexis Bretin,Xi Cheng,Qing Liu,Michael D. Flythe,Benoit Chassaing,Gregory C. Shearer,Andrew D. Patterson,Andrew T. Gewirtz,Matam Vijay-Kumar +15 more
TL;DR: The notion that fermentable fibres have the potential to ameliorate colitis is supported but it is cautioned that, in some contexts, prebiotic fibres can lead to gut dysbiosis and surfeit colonic butyrate that might exacerbate IBD.
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Macrophages: An elusive yet emerging therapeutic target of atherosclerosis
TL;DR: Deciphering the role of macrophages in regulating dyslipidemia and inflammation during atherosclerosis is important for developing them as therapeutic targets.
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Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.
Vishal Singh,Benoit Chassaing,Limin Zhang,Limin Zhang,Beng San Yeoh,Xia Xiao,Manish Kumar,Mark T. Baker,Jingwei Cai,Rachel E Walker,Kamil Borkowski,Kevin J. Harvatine,Nagendra Singh,Gregory C. Shearer,James M. Ntambi,Bina Joe,Andrew D. Patterson,Andrew T. Gewirtz,Matam Vijay-Kumar +18 more
TL;DR: Deletion of hepatic SCD1 not only prevented hepatic neutral lipid oleate enrichment but also ameliorated metabolic syndrome in T5KO mice, underscoring the key role of the gut microbiota-liver axis in the pathogenesis of metabolic diseases.