M
Manuel Banzhaf
Researcher at University of Birmingham
Publications - 43
Citations - 2884
Manuel Banzhaf is an academic researcher from University of Birmingham. The author has contributed to research in topics: Peptidoglycan & Bacterial outer membrane. The author has an hindex of 15, co-authored 32 publications receiving 2242 citations. Previous affiliations of Manuel Banzhaf include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
From the regulation of peptidoglycan synthesis to bacterial growth and morphology
TL;DR: This Review discusses how growth of the sacculus is sensitive to mechanical force and nutritional status, and describes the roles of peptidoglycan hydrolases in generating cell shape and of D-amino acids in sacculus remodelling.
Journal ArticleDOI
Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins
Athanasios Typas,Manuel Banzhaf,H. Bart van den Berg van Saparoea,Jolanda Verheul,Jacob Biboy,Robert J. Nichols,Matylda Zietek,Katrin Beilharz,Kai Kannenberg,Moritz von Rechenberg,Eefjan Breukink,Tanneke den Blaauwen,Carol A. Gross,Waldemar Vollmer +13 more
TL;DR: It is demonstrated that PG synthases are also controlled from outside the sacculus, and the data suggest that the LpoB-PBP1B complex contributes to OM constriction during cell division.
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Species-specific activity of antibacterial drug combinations
Ana Rita Brochado,Anja Telzerow,Jacob Bobonis,Manuel Banzhaf,André Mateus,Joel Selkrig,Emily Huth,Stefan Bassler,Jordi Zamarreño Beas,Matylda Zietek,Natalie Ng,Sunniva Foerster,Benjamin Ezraty,Béatrice Py,Frédéric Barras,Frédéric Barras,Mikhail M. Savitski,Peer Bork,Stephan Göttig,Athanasios Typas +19 more
TL;DR: Screening pairwise combinations of antibiotics and other drugs against three bacterial pathogens reveals that antagonistic and synergistic drug–drug interactions are specific to microbial species and strains.
Journal ArticleDOI
Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway
Benjamin Ezraty,Alexandra Vergnes,Manuel Banzhaf,Yohann Duverger,Allison Huguenot,Ana Rita Brochado,Shu-Yi Su,Leon Espinosa,Laurent Loiseau,Béatrice Py,Athanasios Typas,Frédéric Barras +11 more
TL;DR: It is found that the ROS response is dispensable upon treatment with bactericidal antibiotics, and it is demonstrated that Fe-S clusters are required for killing only by aminoglycosides.
Journal ArticleDOI
Cooperativity of peptidoglycan synthases active in bacterial cell elongation
Manuel Banzhaf,H. Bart van den Berg van Saparoea,Mohammed Terrak,Claudine Fraipont,Alexander J. F. Egan,Jules Philippe,Jules Philippe,André Zapun,André Zapun,Eefjan Breukink,Martine Nguyen-Distèche,Tanneke den Blaauwen,Waldemar Vollmer +12 more
TL;DR: In vitro peptidoglycan synthesis assays provide novel insights into the cooperativity of peptidglycan synthases with different activities, and provide a possible explanation for the depletion of lipid II precursors in penicillin‐treated cells.