M
Manuel Doblado
Researcher at University of California, San Diego
Publications - 9
Citations - 584
Manuel Doblado is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Glucose transporter & Pregnancy. The author has an hindex of 6, co-authored 9 publications receiving 512 citations. Previous affiliations of Manuel Doblado include University of Colorado Denver & Washington University in St. Louis.
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Journal ArticleDOI
SLC2A9 Is a High-Capacity Urate Transporter in Humans
Mark J. Caulfield,Patricia B. Munroe,Deb O'Neill,Kate Witkowska,Fadi J. Charchar,Manuel Doblado,Sarah Evans,Susana Eyheramendy,Abiodun Onipinla,Philip Howard,Sue Shaw-Hawkins,Richard Dobson,Chris Wallace,Stephen Newhouse,Morris J. Brown,John M. C. Connell,Anna Dominiczak,Martin Farrall,G. Mark Lathrop,Nilesh J. Samani,Nilesh J. Samani,Meena Kumari,Michael Marmot,Eric J. Brunner,John C. Chambers,Paul Elliott,Jaspal S. Kooner,Maris Laan,Elin Org,Gudrun Veldre,Margus Viigimaa,Francesco P. Cappuccio,Chen Ji,Roberto Iacone,Pasquale Strazzullo,Kelle H. Moley,Chris I. Cheeseman +36 more
TL;DR: Evidence is provided that SLC2A9 splice variants act as high-capacity urate transporters and is one of the first functional characterisations of findings from genome-wide association scans.
Journal ArticleDOI
Facilitative glucose transporter 9, a unique hexose and urate transporter.
Manuel Doblado,Kelle H. Moley +1 more
TL;DR: There is evidence that uric acid may play a role in the pathogenesis of metabolic syndrome, obesity, diabetes, hypertension, and chronic renal failure, and several recent large-scale human genetic studies show a correlation between SNPs mapped to GLUT9 and the serum uric Acid levels in several different cohorts.
Journal ArticleDOI
Facilitative Glucose Transporter 9 Expression Affects Glucose Sensing in Pancreatic β-Cells
TL;DR: It is demonstrated that GLUT9a andGLUT9b are expressed in pancreatic islets and that this expression localizes to insulin-containing beta-cells, suggesting that GLut9 may participate in glucose-sensing in beta- cells.
Journal ArticleDOI
Glucose metabolism in pregnancy and embryogenesis.
Manuel Doblado,Kelle H. Moley +1 more
TL;DR: Although the exact pathophysiology of the developmental defects seen in infants born to diabetic mothers remains unclear, the role of glucose transport and regulation seems to play a critical role in early growth and development.
Journal ArticleDOI
In vitro fertilization after bariatric surgery
TL;DR: IVF is a safe and effective fertility treatment for these women, although special considerations should be made when treating patients who have undergone bariatric surgery, considering the type of bypass procedure the patient underwent.