Sarah Evans

TL;DR: Evidence is provided that SLC2A9 splice variants act as high-capacity urate transporters and is one of the first functional characterisations of findings from genome-wide association scans.

TL;DR: It is demonstrated that ferrostatin-1 (Fer-1), a specific inhibitor of ferroptosis, decreases the level of pro-ferroptotic hydroperoxy-arachidonoyl-phosphatidylethanolamine, reduces cardiomyocyte cell death and blocks neutrophil recruitment following heart transplantation.

TL;DR: These studies constitute the initial demonstration that DAMPs released by NMCs induce fibroblast activation in vitro, as well as myocardial inflammation and fibrosis in vivo, at least in part, through TLR4-dependent signaling.

TL;DR: The expression profile of messenger RNAs in the heart of septic patients reveals striking decreases in expression levels of messengerRNAs that encode proteins involved in cardiac energy production and cardiac contractility and is distinct from that observed in patients with heart failure.

TL;DR: It is found that myocardial B cells represent a subpopulation of circulating B cells that make close contact with the microvascular endothelium of the heart and arrest their transit as they pass through the heart.