J
Jeremy Leipzig
Researcher at Drexel University
Publications - 40
Citations - 5657
Jeremy Leipzig is an academic researcher from Drexel University. The author has contributed to research in topics: Virus Integration & HIV integration. The author has an hindex of 29, co-authored 40 publications receiving 5153 citations. Previous affiliations of Jeremy Leipzig include University of Pennsylvania & North Carolina State University.
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De novo mutations in histone-modifying genes in congenital heart disease
Samir Zaidi,Murim Choi,Hiroko Wakimoto,Lijiang Ma,Jianming Jiang,John D. Overton,Angela Romano-Adesman,Robert D. Bjornson,Roger E. Breitbart,Kerry K. Brown,Nicholas Carriero,Yee Him Cheung,John E. Deanfield,Steve Depalma,Khalid Adnan Mohamed A. Fakhro,Joseph T. Glessner,Hakon Hakonarson,Michael J. Italia,Jonathan R. Kaltman,Juan Pablo Kaski,Richard B. Kim,Jennie Kline,Teresa Lee,Jeremy Leipzig,Alexander Lopez,Shrikant Mane,Laura E. Mitchell,Jane W. Newburger,Michael Parfenov,Itsik Pe'er,George A. Porter,Amy E. Roberts,Ravi Sachidanandam,Stephen Sanders,Howard S. Seiden,Mathew W. State,Sai Lakshmi Subramanian,Irina Tikhonova,Wei Wang,Wei Wang,Dorothy Warburton,Peter White,Ismee A. Williams,Hongyu Zhao,Jonathan G. Seidman,Martina Brueckner,Wendy K. Chung,Bruce D. Gelb,Elizabeth Goldmuntz,Christine E. Seidman,Richard P. Lifton +50 more
TL;DR: Comparing the incidence of de novo mutations in severe CHD cases and controls by analysing exome sequencing of parent–offspring trios suggests that several hundreds of genes collectively contribute to approximately 10% of severeCHD.
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A role for LEDGF/p75 in targeting HIV DNA integration.
Angela Ciuffi,Manuel Llano,Eric M. Poeschla,Christian Hoffmann,Jeremy Leipzig,Paul Shinn,Joseph R. Ecker,Frederic D. Bushman +7 more
TL;DR: LEDGF is the first example of a cellular protein controlling the location of HIV integration in human cells and it is found that integration was less frequent in transcription units, lessrequent in genes regulated by LEDGF/p75 and more frequent in GC-rich DNA.
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HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications
TL;DR: Using pyrosequencing to map 40,569 unique sites of HIV integration indicated that integration sites are periodically distributed on the nucleosome surface, consistent with favored integration into outward-facing DNA major grooves in chromatin.
Journal ArticleDOI
Genome-wide analysis of retroviral DNA integration
Frederic D. Bushman,Mary K. Lewinski,Angela Ciuffi,Stephen D. Barr,Jeremy Leipzig,Sridhar Hannenhalli,Christian Hoffmann +6 more
TL;DR: This work reviews retroviral DNA integration, with emphasis on recent genome-wide studies of targeting and on the status of efforts to modulate target-site selection.
Journal ArticleDOI
mtDNA Variation and Analysis Using Mitomap and Mitomaster
Marie T. Lott,Jeremy Leipzig,Olga Derbeneva,H. Michael Xie,Dimitra Chalkia,Mahdi Sarmady,Vincent Procaccio,Douglas C. Wallace,Douglas C. Wallace +8 more
TL;DR: The Mitomap protocol shows how users may look up human mitochondrial gene loci, search for public mitochondrial sequences, and browse or search for reported general population nucleotide variants as well as those reported in clinical disease.