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Angela Ciuffi
Researcher at University of Lausanne
Publications - 81
Citations - 4915
Angela Ciuffi is an academic researcher from University of Lausanne. The author has contributed to research in topics: Viral replication & Gene. The author has an hindex of 31, co-authored 71 publications receiving 4458 citations. Previous affiliations of Angela Ciuffi include University Hospital of Lausanne & University of California, San Diego.
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Journal ArticleDOI
A role for LEDGF/p75 in targeting HIV DNA integration.
Angela Ciuffi,Manuel Llano,Eric M. Poeschla,Christian Hoffmann,Jeremy Leipzig,Paul Shinn,Joseph R. Ecker,Frederic D. Bushman +7 more
TL;DR: LEDGF is the first example of a cellular protein controlling the location of HIV integration in human cells and it is found that integration was less frequent in transcription units, lessrequent in genes regulated by LEDGF/p75 and more frequent in GC-rich DNA.
Journal ArticleDOI
HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications
TL;DR: Using pyrosequencing to map 40,569 unique sites of HIV integration indicated that integration sites are periodically distributed on the nucleosome surface, consistent with favored integration into outward-facing DNA major grooves in chromatin.
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Genome-wide analysis of retroviral DNA integration
Frederic D. Bushman,Mary K. Lewinski,Angela Ciuffi,Stephen D. Barr,Jeremy Leipzig,Sridhar Hannenhalli,Christian Hoffmann +6 more
TL;DR: This work reviews retroviral DNA integration, with emphasis on recent genome-wide studies of targeting and on the status of efforts to modulate target-site selection.
Journal ArticleDOI
Retroviral DNA Integration: Viral and Cellular Determinants of Target-Site Selection
Mary K. Lewinski,Masahiro Yamashita,Michael Emerman,Angela Ciuffi,Heather M. Marshall,Gregory E. Crawford,Francis S. Collins,Paul Shinn,Jeremy Leipzig,Sridhar Hannenhalli,Charles C. Berry,Joseph R. Ecker,Frederic D. Bushman,Frederic D. Bushman +13 more
TL;DR: It is found that transferring the MLV integrase (IN) coding region into HIV (to make HIVmIN) caused the hybrid to integrate with a specificity close to that of MLV, revealing that IN is the principal viral determinant of integration specificity.
Journal ArticleDOI
KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading
Anna C. Groner,Sylvain Meylan,Angela Ciuffi,Nadine Zangger,Giovanna Ambrosini,Giovanna Ambrosini,Nicolas Dénervaud,Philipp Bucher,Philipp Bucher,Didier Trono +9 more
TL;DR: It is demonstrated that KRAB and its corepressor KAP1 can silence promoters located several tens of kilobases away from their DNA binding sites, with an efficiency which is generally higher for promoters located within 15 kb or less.