M
Manuela Santonocito
Researcher at University of Catania
Publications - 7
Citations - 368
Manuela Santonocito is an academic researcher from University of Catania. The author has contributed to research in topics: Transcriptome & Oocyte. The author has an hindex of 5, co-authored 5 publications receiving 296 citations.
Papers
More filters
Journal ArticleDOI
Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation.
Manuela Santonocito,Marilena Vento,Maria Rosa Guglielmino,Rosalia Battaglia,Jessica Wahlgren,Marco Ragusa,Davide Barbagallo,Placido Borzì,Simona Rizzari,Marco Maugeri,Paolo Scollo,Carla Tatone,Hadi Valadi,Michele Purrello,Cinzia Di Pietro +14 more
TL;DR: This study identified a series of exosomal microRNAs that are highly represented in human FF and are involved in follicular maturation and could represent noninvasive biomarkers of oocyte quality in assisted reproductive technology.
Journal ArticleDOI
Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors
Marco Ragusa,Luisa Statello,Marco Maugeri,Alessandra Majorana,Davide Barbagallo,Loredana Salito,Mariangela Sammito,Manuela Santonocito,Rosario Angelica,Andrea Cavallaro,Marina Scalia,Rosario Caltabiano,Giuseppe Privitera,Antonio Biondi,Maria Di Vita,Alessandro Cappellani,E Vasquez,Salvatore Lanzafame,Elisabetta Tendi,Salvatore Celeste,Cinzia Di Pietro,Francesco Basile,Michele Purrello +22 more
TL;DR: Results contribute to deepen current knowledge on still uncharacterized features of MAPK/ERK pathway, pinpointing new oncomiRs in CRC and allowing their translation into clinical practice and CRC therapy.
Journal ArticleDOI
TAp73 is downregulated in oocytes from women of advanced reproductive age
Maria Rosa Guglielmino,Manuela Santonocito,Marilena Vento,Marco Ragusa,Davide Barbagallo,Placido Borzì,Ida Casciano,Barbara Banelli,Ottavia Barbieri,Simonetta Astigiano,Paolo Scollo,Massimo Romani,Michele Purrello,Cinzia Di Pietro +13 more
TL;DR: TAp73 down regulation in oocytes from women of advanced reproductive age could explain both the reduction of fertility and the increase of newborns with chromosomal abnormalities.
Journal ArticleDOI
Molecular profiling of human oocytes after vitrification strongly suggests that they are biologically comparable with freshly isolated gametes
Cinzia Di Pietro,Marilena Vento,Maria Rosa Guglielmino,Placido Borzì,Manuela Santonocito,Marco Ragusa,Davide Barbagallo,Laura R Duro,Alessandra Majorana,Adele De Palma,M. R. Garofalo,Elisa Minutolo,Paolo Scollo,Michele Purrello +13 more
TL;DR: The comparison of the molecular profiles demonstrated that the vitrification protocol does not alter the biomolecular quality of oocytes, and this cryopreservation technique might be helpful in preserving women's fertility.
Journal ArticleDOI
The apoptotic transcriptome of the human MII oocyte: characterization and age-related changes
Manuela Santonocito,Maria Rosa Guglielmino,Marilena Vento,Marco Ragusa,Davide Barbagallo,Placido Borzì,Ida Casciano,Paolo Scollo,Massimo Romani,Carla Tatone,Michele Purrello,Cinzia Di Pietro +11 more
TL;DR: During maturation the oocytes from older women selectively accumulate mRNAs that are able to trigger the extrinsic apoptotic pathway, and these data contribute to clarify the molecular mechanisms of AM involvement in the natural selection strategy of removing low quality oocytes and preventing unfit or poorly fit embryos.