Marc Boehning

TL;DR: It is reported that human and yeast CTDs undergo cooperative liquid phase separation, with the shorter yeast CTD forming less-stable droplets and that CTD phosphorylation liberates Pol II enzymes from hubs for promoter escape and transcription elongation.

TL;DR: In this article, the authors showed that the formation of an activated Pol II elongation complex in vitro requires the kinase function of the positive transcription elongation factor b (P-TEFb) and the elongation factors PAF1 complex (PAF) and SPT6.

TL;DR: Two active mechanisms that can explain how cells regulate condensate formation and size are proposed and can guide studies into the many emerging roles of biomolecular condensates.

TL;DR: In this paper, the negative elongation factor (NELF) is recruited to gene promoters to impair RNA polymerase II elongation, which is required for cellular viability under stressful conditions.

TL;DR: A previously unreported phytase activity of the alkaline phosphatase and sulfatase superfamily and of purple acid phosphatases from nonvegetal origin is revealed, suggesting that the classical concept comprising four classes of phytases should be modified and indicates high performance of the screening method for retrieving novel types of phosphatased/phytases hidden in metagenomes of complex environments.