M
Marc F. Poitras
Researcher at Johns Hopkins University
Publications - 9
Citations - 2870
Marc F. Poitras is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Poly ADP ribose polymerase & Poly(ADP-ribose) glycohydrolase. The author has an hindex of 8, co-authored 9 publications receiving 2737 citations. Previous affiliations of Marc F. Poitras include New York University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.
Seong-Woon Yu,Hongmin Wang,Marc F. Poitras,Carmen Coombs,William J. Bowers,Howard J. Federoff,Guy G. Poirier,Ted M. Dawson,Valina L. Dawson +8 more
TL;DR: It is shown that PARP-1 activation is required for translocation of apoptosis-inducing factor (AIF) from the mitochondria to the nucleus and that AIF is necessary for PARp-1–dependent cell death.
Journal ArticleDOI
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality
David W. Koh,Ann M. Lawler,Marc F. Poitras,Marc F. Poitras,Masayuki Sasaki,Sigrid Wattler,Michael Nehls,Tobias Stöger,Guy G. Poirier,Valina L. Dawson,Ted M. Dawson +10 more
TL;DR: A role for PARG in embryonic development and a protective role in the response to genotoxic stress are defined, providing compelling evidence that the failure to degrade PAR has deleterious consequences.
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PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury.
Henrik Hagberg,Mary Ann Wilson,Mary Ann Wilson,Hiroko Matsushita,Changlian Zhu,Mary S. Lange,Malin Gustavsson,Marc F. Poitras,Ted M. Dawson,Valina L. Dawson,Frances J. Northington,Michael V. Johnston +11 more
TL;DR: The results indicate that hypoxia‐ischemia activates Poly(ADP‐ribose) polymerase‐1 in the neonatal brain and that the sex of the animal strongly influences its role in the pathogenesis of brain injury.
Journal ArticleDOI
NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase
Allen S. Mandir,Marc F. Poitras,Adam R. Berliner,William J. Herring,Daniel Guastella,Alicia Feldman,Guy G. Poirier,Zhao-Qi Wang,Ted M. Dawson,Valina L. Dawson +9 more
TL;DR: A selective role of PARP-1 in glutamate excitoxicity is suggested, and strategies of inhibiting PARP -1 in NMDA-mediated neurotoxicity may offer substantial acute and chronic neuroprotection.
Journal ArticleDOI
Poly(ADP-Ribose) Polymerase Impairs Early and Long-Term Experimental Stroke Recovery
Shozo Goto,Rong Xue,Nobuo Sugo,Masahiko Sawada,Kathleen K. Blizzard,Marc F. Poitras,David C. Johns,Ted M. Dawson,Valina L. Dawson,Barbara J. Crain,Richard J. Traystman,Susumu Mori,Patricia D. Hurn +12 more
TL;DR: PARP-1 deficiency provides both early and prolonged protection from experimental focal stroke, and the mechanism is not linked to preservation of ADC and mitigation of secondary energy depletion during early reperfusion.