M
Marc Leone
Researcher at Aix-Marseille University
Publications - 494
Citations - 15278
Marc Leone is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Medicine & Intensive care unit. The author has an hindex of 56, co-authored 420 publications receiving 11460 citations. Previous affiliations of Marc Leone include Nord University & Institut de recherche pour le développement.
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Journal ArticleDOI
A trial of intraoperative low-tidal-volume ventilation in abdominal surgery.
Emmanuel Futier,Jean-Michel Constantin,Catherine Paugam-Burtz,Julien Pascal,Mathilde Eurin,Arthur Neuschwander,Emmanuel Marret,Marc Beaussier,Christophe Gutton,Jean-Yves Lefrant,Bernard Allaouchiche,Daniel Verzilli,Marc Leone,Audrey De Jong,Jean-Etienne Bazin,Bruno Pereira,Samir Jaber +16 more
TL;DR: The use of a lung-protective ventilation strategy in intermediate-risk and high-risk patients undergoing major abdominal surgery was associated with improved clinical outcomes and reduced health care utilization.
Journal ArticleDOI
Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial
Emmanuel Futier,Jean-Yves Lefrant,Pierre-Grégoire Guinot,Thomas Godet,Emmanuel Lorne,Philippe Cuvillon,Sébastien Bertran,Marc Leone,Bruno Pastene,Vincent Piriou,Serge Molliex,Jacques Albanèse,Jean-Michel Julia,Benoît Tavernier,Etienne Imhoff,Jean-Étienne Bazin,Jean-Michel Constantin,Bruno Pereira,Samir Jaber +18 more
TL;DR: Among patients predominantly undergoing abdominal surgery who were at increased postoperative risk, management targeting an individualized systolic blood pressure management strategy compared with standard management, reduced the risk of postoperative organ dysfunction.
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Effect of norepinephrine on the outcome of septic shock.
TL;DR: The results indicate that the use of norepinephrine as part of hemodynamic management may influence outcome favorably in septic shock patients, and contradict the notion that norpinephrine potentiates end-organ hypoperfusion, thereby contributing to increased mortality.
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Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function.
TL;DR: Increasing mean arterial pressure from 65 to 85 mm Hg with norepinephrine neither affects metabolic variables nor improves renal function.
Journal ArticleDOI
Respiratory variations of inferior vena cava diameter to predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure: need for a cautious use
Laurent Muller,Xavier Bobbia,Mehdi Toumi,Guillaume Louart,Nicolas Molinari,B Ragonnet,Hervé Quintard,Marc Leone,Lana Zoric,Jean Yves Lefrant +9 more
TL;DR: In spontaneously breathing patients with ACF, high cIVC values (>40%) are usually associated with fluid responsiveness while low values (< 40%) do not exclude fluid responsiveness.