M
Marcel Garcia
Researcher at University of Montpellier
Publications - 131
Citations - 6661
Marcel Garcia is an academic researcher from University of Montpellier. The author has contributed to research in topics: Cathepsin D & Mesoporous silica. The author has an hindex of 45, co-authored 127 publications receiving 6298 citations. Previous affiliations of Marcel Garcia include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis
Emmanuelle Liaudet-Coopman,Mélanie Beaujouin,Danielle Derocq,Marcel Garcia,Murielle Glondu-Lassis,Valérie Laurent-Matha,Christine Prébois,Henri Rochefort,Françoise Vignon +8 more
TL;DR: This review summarises the current knowledge on cath-D action in cancer progression and metastasis, as well as its dual function in apoptosis.
Journal Article
Association between High Concentrations of Mr 52,000 Cathepsin D and Poor Prognosis in Primary Human Breast Cancer
Susan M. Thorpe,Henri Rochefort,Marcel Garcia,Gilles Freiss,Ib Jarle Christensen,Siham Khalaf,Francis Paolucci,Bernard Pau,Birgitte Bruun Rasmussen,Carsten Rose +9 more
TL;DR: It is demonstrated that the level of Mr 52,000 cathepsin D in cytosol of primary breast cancer biopsies is an independent prognostic factor in predicting relapses in both pre/peri- and postmenopausal patients.
Journal ArticleDOI
Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis.
Guy Berchem,Murielle Glondu,Michel Gleizes,Jean-Paul Brouillet,Françoise Vignon,Marcel Garcia,Emmanuelle Liaudet-Coopman +6 more
TL;DR: It is proposed that human cathepsin-D stimulates tumor growth by acting–directly or indirectly–as a mitogenic factor on both cancer and endothelial cells independently of its catalytic activity.
Journal ArticleDOI
Mannose-functionalized mesoporous silica nanoparticles for efficient two-photon photodynamic therapy of solid tumors.
Magali Gary-Bobo,Youssef Mir,Cédric Rouxel,David Brevet,Ilaria Basile,Marie Maynadier,Ophélie Vaillant,Olivier Mongin,Mireille Blanchard-Desce,Alain Morère,Marcel Garcia,Jean-Olivier Durand,Laurence Raehm +12 more
TL;DR: In the context of national systematic screenings for cancer,photodynamic therapy (PDT) has arisen as an alternative tochemo- and radiotherapy for the non-invasive selectivedestruction of small tumors.
Journal ArticleDOI
Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy.
David Brevet,Magali Gary-Bobo,Laurence Raehm,Sébastien Richeter,Ouahiba Hocine,Kassem Amro,Bernard Loock,Pierre Couleaud,Céline Frochot,Alain Morère,Philippe Maillard,Marcel Garcia,Jean-Olivier Durand +12 more
TL;DR: Functionalisation of MSN with mannose for PDT applications dramatically improved the efficiency of PDT on breast cancer cells.