Guy Berchem

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is demonstrated that CLL-derived exosomes actively promote disease progression by modulating several functions of surrounding stromal cells that acquire features of cancer-associated fibroblasts, contributing to a tumor-supportive microenvironment.

TL;DR: It is proposed that human cathepsin-D stimulates tumor growth by acting–directly or indirectly–as a mitogenic factor on both cancer and endothelial cells independently of its catalytic activity.

TL;DR: It is demonstrated that hypoxia impairs breast cancer cell susceptibility to NK-mediated lysis in vitro via the activation of autophagy, which provides a cutting-edge advance in the understanding of the mechanism by which hyp oxia-induced autophagic impairs NK-mediation in vitro and paves the way for the formulation of more effective NK cell-based antitumor therapies.

TL;DR: Investigating whether the expression in tumors of a secreted fibroblast growth factor-binding protein (FGF-BP) that mobilizes and activates locally stored FGFs can serve as an angiogenic switch molecule found that the reduction of FGF- BP reduced the release of biologically active basic FGF (bFGF) from cells in culture.