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Bernard Pau
Researcher at Centre national de la recherche scientifique
Publications - 160
Citations - 6861
Bernard Pau is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Monoclonal antibody & Epitope. The author has an hindex of 40, co-authored 159 publications receiving 6730 citations. Previous affiliations of Bernard Pau include French Institute of Health and Medical Research & University of Montpellier.
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Journal ArticleDOI
A peptide mimetic of an anti-CD4 monoclonal antibody by rational design
Florence Casset,Florence Roux,Patrick Mouchet,Cédric Bès,Thierry Chardès,Claude Granier,Jean-Claude Mani,Martine Pugnière,Daniel Laune,Bernard Pau,Michel Kaczorek,Roger Lahana,Anthony R. Rees +12 more
TL;DR: Using peptide mapping to determine 'active' antigen recognition residues, molecular modeling, and a molecular dynamics trajectory analysis, a peptide mimic of an anti-CD4 antibody is developed, containing antigen contact residues from multiple CDRs.
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Circulating Cardiac Troponin I in Severe Congestive Heart Failure
TL;DR: These data provide the first evidence for ongoing myofibrillar degradation and increased cardiac troponin I levels in patients with advanced heart failure and show potential usefulness of cardiac trop onin I as a specific and sensitive new serum marker molecule in severe congestive heart failure.
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Cardiac-specific immunoenzymometric assay of troponin I in the early phase of acute myocardial infarction
TL;DR: This assay allows a specific diagnosis of AMI in its early acute phase, with a high diagnostic specificity and sensitivity, and was used to measure cardiac TnI in the plasma of 43 patients with acute myocardial infarction.
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Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells
Hildur E. Blythman,Pierre Casellas,Olivier Gros,Pierre Gros,F.K. Jansen,Francis Paolucci,Bernard Pau,H. Vidal +7 more
TL;DR: The problem of nonspecific binding by the B-piece has been circumvented by using the A-piece only as the toxin component of immunotoxins; these immunOToxins are active both in vitro and in vivo.
Journal Article
Association between High Concentrations of Mr 52,000 Cathepsin D and Poor Prognosis in Primary Human Breast Cancer
Susan M. Thorpe,Henri Rochefort,Marcel Garcia,Gilles Freiss,Ib Jarle Christensen,Siham Khalaf,Francis Paolucci,Bernard Pau,Birgitte Bruun Rasmussen,Carsten Rose +9 more
TL;DR: It is demonstrated that the level of Mr 52,000 cathepsin D in cytosol of primary breast cancer biopsies is an independent prognostic factor in predicting relapses in both pre/peri- and postmenopausal patients.