M
Marcela Henao-Tamayo
Researcher at Colorado State University
Publications - 64
Citations - 2945
Marcela Henao-Tamayo is an academic researcher from Colorado State University. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 27, co-authored 56 publications receiving 2541 citations.
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Journal ArticleDOI
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
Karim C. El Kasmi,Joseph E. Qualls,John T. Pesce,Amber M. Smith,Robert W. Thompson,Marcela Henao-Tamayo,Randall J. Basaraba,Till König,Ulrike Schleicher,Mi-Sun Koo,Gilla Kaplan,Katherine A. Fitzgerald,Elaine Tuomanen,Ian M. Orme,Thirumala-Devi Kanneganti,Christian Bogdan,Thomas A. Wynn,Peter J. Murray +17 more
TL;DR: A 'loophole' in the TLR pathway that is advantageous to intracellular pathogens is reported that favored host survival during T. gondii infection and decreased lung bacterial load during tuberculosis infection.
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The Hypervirulent Mycobacterium tuberculosis Strain HN878 Induces a Potent TH1 Response followed by Rapid Down-Regulation
Diane J. Ordway,Marcela Henao-Tamayo,Marisa Harton,Gopinath S. Palanisamy,JoLynn Troudt,Crystal A. Shanley,Randall J. Basaraba,Ian M. Orme +7 more
TL;DR: It is demonstrated that although type I IFN does play an inhibitory role, this response was most apparent during the chronic disease stage and was common to all M. tuberculosis strains tested.
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A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis
Kari Sweeney,Dee N. Dao,Michael F. Goldberg,Tsungda Hsu,Manjunatha M. Venkataswamy,Marcela Henao-Tamayo,Diane J. Ordway,Rani S. Sellers,Paras Jain,Bing Chen,Mei Chen,John Kim,Regy Lukose,John Chan,Ian M. Orme,Steven A. Porcelli,William R. Jacobs +16 more
TL;DR: A role for the esx-3 locus is established in promoting mycobacterial virulence and the IKE strain is identified as a potentially powerful candidate vaccine vector for eliciting protective immunity to M. tuberculosis.
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Animal model of Mycobacterium abscessus lung infection
Diane J. Ordway,Marcela Henao-Tamayo,Erin E. Smith,Crystal A. Shanley,Marisa Harton,JoLynn Troudt,Xiyuan Bai,Randall J. Basaraba,Ian M. Orme,Edward D. Chan,Edward D. Chan +10 more
TL;DR: It is shown that IFN‐γ is critically important in the host defense against M. abscessus and the GKO mice provide a model for in vivo testing of novel drugs.
Journal ArticleDOI
The Cellular Immune Response to Mycobacterium tuberculosis Infection in the Guinea Pig
Diane J. Ordway,Gopinath S. Palanisamy,Marcela Henao-Tamayo,Erin E. Smith,Crystal A. Shanley,Ian M. Orme,Randall J. Basaraba +6 more
TL;DR: Results show that the responding T cells are mostly CD4 cells and that after day 30 of the infection numbers of these cells in the lungs drops dramatically, and these appear to be replaced by a steady increase in B cells and granulocytes which was associated with worsening lung pathology.