A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis
Kari Sweeney,Dee N. Dao,Michael F. Goldberg,Tsungda Hsu,Manjunatha M. Venkataswamy,Marcela Henao-Tamayo,Diane J. Ordway,Rani S. Sellers,Paras Jain,Bing Chen,Mei Chen,John Kim,Regy Lukose,John Chan,Ian M. Orme,Steven A. Porcelli,William R. Jacobs +16 more
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TLDR
A role for the esx-3 locus is established in promoting mycobacterial virulence and the IKE strain is identified as a potentially powerful candidate vaccine vector for eliciting protective immunity to M. tuberculosis.Abstract:
New vaccine candidates are urgently needed for the control and prevention of Mycobacterium tuberculosis (Mtb) infection. Kari Sweeney and her colleagues now report that an attenuated strain of Mycobacterium smegmatis expressing the esx-3 genes from Mtb induces effective CD4+ T cell dependent immunity against infection with Mtb in mice. The study offers a new avenue for the identification of protective immunogens in Mtb infection and a candidate vaccine platform warranting further study.read more
Citations
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Vaccines against tuberculosis: where are we and where do we need to go?
TL;DR: There is good reason for optimism in the field of TB vaccines that it will be possible to develop better vaccines than BCG, which is still the only vaccine available against TB.
Journal ArticleDOI
Scaling up interventions to achieve global tuberculosis control: progress and new developments
Mario C. Raviglione,Ben J. Marais,Katherine Floyd,Knut Lönnroth,Haileyesus Getahun,Giovanni Battista Migliori,Anthony D. Harries,Anthony D. Harries,Paul Nunn,Christian Lienhardt,Steve Graham,Steve Graham,Jeremiah Chakaya,Karin Weyer,Stewart T. Cole,Stefan H. E. Kaufmann,Alimuddin Zumla +16 more
TL;DR: With improved control efforts, the world and most regions are on track to achieve the Millennium Development Goal of decreasing tuberculosis incidence by 2015, and the Stop TB Partnership target of halving 1990 mortality rates by 2015; the exception is Africa.
Journal ArticleDOI
ESX secretion systems: mycobacterial evolution to counter host immunity
TL;DR: The intriguing roles that these studies have revealed for ESX systems in bacterial survival and pathogenicity during infection with M. tuberculosis are highlighted and how the knowledge of these systems might be applied to the development of novel strategies for the treatment and prevention of disease is considered.
Journal ArticleDOI
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease.
Shunsuke Sakai,Keith D. Kauffman,Michelle A. Sallin,Arlene H. Sharpe,Howard A. Young,Vitaly V. Ganusov,Daniel L. Barber +6 more
TL;DR: The primary role for T cell-derived IFN-γ in Mtb infection is at extra-pulmonary sites, and the host-protective subset of CD4 T cells requires negative regulation of IFN–γ production by PD-1 to prevent lethal immune-mediated pathology.
Journal ArticleDOI
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset
Cecilia S. Lindestam Arlehamn,Anna Gerasimova,Federico Mele,Ryan Henderson,Justine Swann,Jason A. Greenbaum,Yohan Kim,John Sidney,Eddie A. James,Randy Taplitz,Denise M. McKinney,William W. Kwok,Howard M. Grey,Federica Sallusto,Bjoern Peters,Alessandro Sette +15 more
TL;DR: The results underline the power of a truly unbiased, genome-wide, analysis of CD4 MTB recognition based on the combined use of epitope predictions, high throughput ELISPOT, and T cell libraries using PBMCs from individuals latently infected with MTB.
References
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Journal ArticleDOI
Global Burden of Tuberculosis: Estimated Incidence, Prevalence, and Mortality by Country
TL;DR: The global burden of tuberculosis remains enormous, mainly because of poor control in Southeast Asia, sub-Saharan Africa, and eastern Europe, and because of high rates of M tuberculosis and HIV coinfection in some African countries.
Journal ArticleDOI
The growing burden of tuberculosis: global trends and interactions with the HIV epidemic.
Elizabeth L. Corbett,Catherine J. Watt,Neff Walker,Dermot Maher,Brian G. Williams,Mario C. Raviglione,Christopher Dye +6 more
TL;DR: The prevention of HIV and TB, the extension of WHO DOTS programs, and a focused effort to control HIV-related TB in areas of high HIV prevalence are matters of great urgency.
Journal ArticleDOI
Genes required for mycobacterial growth defined by high density mutagenesis
TL;DR: The use of transposon site hybridization (TraSH) is described to comprehensively identify the genes required by the causative agent, Mycobacterium tuberculosis, for optimal growth, suggesting that the minimal gene set required for survival varies greatly between organisms with different evolutionary histories.
Journal ArticleDOI
Immunology of tuberculosis.
JoAnne L. Flynn,John W. Y. Chan +1 more
TL;DR: This review summarizes the current understanding of the host immune response, with emphasis on the roles of macrophages, T cells, and the cytokine/chemokine network in engendering protective immunity.
Journal ArticleDOI
Efficacy of BCG Vaccine in the Prevention of Tuberculosis: Meta-analysis of the Published Literature
Graham A. Colditz,Timothy F. Brewer,Catherine S. Berkey,Mary E. Wilson,Elisabeth Burdick,Harvey V. Fineberg,Frederick Mosteller +6 more
TL;DR: Protection against tuberculous death, meningitis, and disseminated disease is higher than for total TB cases, although this result may reflect reduced error in disease classification rather than greater BCG efficacy.
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