D
Diane J. Ordway
Researcher at Colorado State University
Publications - 120
Citations - 6268
Diane J. Ordway is an academic researcher from Colorado State University. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 42, co-authored 112 publications receiving 5456 citations. Previous affiliations of Diane J. Ordway include Universidade Nova de Lisboa & University of Lisbon.
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Journal ArticleDOI
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
Josephine M. Bryant,Josephine M. Bryant,Dorothy M Grogono,Dorothy M Grogono,Daniela Rodriguez-Rincon,Isobel Everall,Karen Brown,Karen Brown,Pablo Moreno,Deepshikha Verma,Emily Hill,Judith Drijkoningen,Peter H. Gilligan,Charles R. Esther,Peadar G. Noone,Olivia Giddings,Scott C. Bell,Scott C. Bell,Rachel Thomson,Claire E. Wainwright,Claire E. Wainwright,Chris Coulter,Sushil Pandey,Michelle Wood,Michelle Wood,Rebecca E Stockwell,Rebecca E Stockwell,Kay A. Ramsay,Kay A. Ramsay,Laura J. Sherrard,Timothy J. Kidd,Timothy J. Kidd,Nassib Jabbour,Graham R. Johnson,Luke D. Knibbs,Lidia Morawska,Peter D. Sly,Andrew Jones,Diana Bilton,Ian F. Laurenson,Michael Ruddy,Stephen Bourke,Ian C. J. W. Bowler,Stephen J Chapman,Andrew Clayton,Mairi Cullen,Owen J. Dempsey,Miles Denton,M. Desai,Richard J Drew,Frank Edenborough,Jason T. Evans,Jonathan Folb,Thomas Daniels,Helen Humphrey,Barbara Isalska,Søren Jensen-Fangel,Bodil Jönsson,Andrew M Jones,Terese L. Katzenstein,Troels Lillebaek,Gordon MacGregor,Sarah Mayell,Michael Millar,Deborah E. Modha,Edward F. Nash,C. O'Brien,Deirdre O'Brien,Chandra Ohri,Caroline S. Pao,Daniel Peckham,Felicity Perrin,Audrey Perry,Tania Pressler,Laura Prtak,Tavs Qvist,Ali Robb,Helen Rodgers,Kirsten Schaffer,Nadia Shafi,Jakko van Ingen,Martin Walshaw,Danie Watson,Noreen West,Joanna L. Whitehouse,Charles S. Haworth,Simon R. Harris,Diane J. Ordway,Julian Parkhill,R. Andres Floto,R. Andres Floto +90 more
TL;DR: Using whole-genome analysis of a global collection of clinical isolates, it is shown that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally.
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Josephine M. Bryant,Dorothy M Grogono,Daniela Rodriguez-Rincon,Isobel Everall,Karen Brown,Pablo Moreno,Deepshikha Verma,E. Hill,J. Drijkoningen,Peter H. Gilligan,Charles R. Esther,Peadar G. Noone,Olivia Giddings,Scott C. Bell,Rachel Thomson,Claire E. Wainwright,Chris Coulter,Sushil Pandey,Michelle Wood,Rebecca E Stockwell,Kay A. Ramsay,Laura J. Sherrard,Timothy J. Kidd,Nassib Jabbour,Graham R. Johnson,Luke D. Knibbs,Lidia Morawska,Peter D. Sly,Alison Jones,Diana Bilton,Ian F. Laurenson,Michael Ruddy,Stephen Bourke,Ian C. J. W. Bowler,Stephen J Chapman,Andrew Clayton,M. Cullen,Owen J. Dempsey,Miles Denton,M. Desai,R. J. Drew,F. Edenborough,Jason T. Evans,Jonathan Folb,T. Daniels,H. Humphrey,B. Isalska,Søren Jensen-Fangel,Bodil Jönsson,Andrew Jones,Terese L. Katzenstein,Troels Lillebaek,Gordon MacGregor,S. Mayell,Michael Millar,Deborah E. Modha,Edward F. Nash,C. O'Brien,D. OBrien,Chandra Ohri,Caroline S. Pao,Daniel Peckham,Felicity Perrin,Audrey Perry,Tacjana Pressler,L. Prtak,Tavs Qvist,A. Robb,Helen Rodgers,K. Schaffer,Nadia Shafi,J. van Ingen,M. Walshaw,D. Watson,Noreen West,Joanna L. Whitehouse,Charles S. Haworth,Simon R. Harris,Diane J. Ordway,Julian Parkhill,R.A. Floto +80 more
TL;DR: In this paper, the authors used whole-genome analysis of a global collection of clinical isolates to show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones.
Journal ArticleDOI
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection
Maurizio Renna,Catherine Schaffner,Karen Brown,Shaobin Shang,Marcela Henao Tamayo,Krisztina Hegyi,Neil Grimsey,David Cusens,Sarah Coulter,Jason D. Cooper,Anne R. Bowden,Sandra M. Newton,Beate Kampmann,Jennifer Helm,Andrew Jones,Charles S. Haworth,Randall J. Basaraba,Mary Ann DeGroote,Diane J. Ordway,David C. Rubinsztein,R. Andres Floto +20 more
TL;DR: It is found that in primary human macrophages, concentrations of azithromycin achieved during therapeutic dosing blocked autophagosome clearance by preventing lysosomal acidification, thereby impairing autophagic and phagosomal degradation and resulted in chronic infection with NTM in mice.
Journal ArticleDOI
A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug Resistant Mycobacterium tuberculosis
Sylvie Bertholet,Gregory C. Ireton,Diane J. Ordway,Hillarie Plessner Windish,Samuel O. Pine,Maria Kahn,Tony Phan,Ian M. Orme,Thomas S. Vedvick,Susan L. Baldwin,Rhea N. Coler,Steven G. Reed +11 more
TL;DR: Data is presented that suggest that a vaccine based on immunization with an oil-in-water adjuvant and a recombinant four-protein fusion protein may be appropriately tested in a human clinical trial and the approach presented in this paper is a promising one.
Journal ArticleDOI
The Hypervirulent Mycobacterium tuberculosis Strain HN878 Induces a Potent TH1 Response followed by Rapid Down-Regulation
Diane J. Ordway,Marcela Henao-Tamayo,Marisa Harton,Gopinath S. Palanisamy,JoLynn Troudt,Crystal A. Shanley,Randall J. Basaraba,Ian M. Orme +7 more
TL;DR: It is demonstrated that although type I IFN does play an inhibitory role, this response was most apparent during the chronic disease stage and was common to all M. tuberculosis strains tested.