M
Marcelo A. Lima
Researcher at Keele University
Publications - 89
Citations - 1887
Marcelo A. Lima is an academic researcher from Keele University. The author has contributed to research in topics: Heparin & Heparan sulfate. The author has an hindex of 20, co-authored 77 publications receiving 1324 citations. Previous affiliations of Marcelo A. Lima include Federal University of Rio Grande do Norte & Federal University of São Paulo.
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Journal ArticleDOI
Heparan sulfate and heparin interactions with proteins
Maria Cecília Zorél Meneghetti,Ashley J. Hughes,Timothy R. Rudd,Helena B. Nader,Andrew K. Powell,Edwin A. Yates,Marcelo A. Lima +6 more
TL;DR: It is argued that the evidence supports both a level of redundancy and a degree of selectivity in the structure–activity relationship between HS and heparin.
Posted ContentDOI
The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
Courtney J. Mycroft-West,Dunhao Su,Stefano Elli,Yong Li,Scott E. Guimond,Gavin J. Miller,Jeremy E. Turnbull,Edwin A. Yates,Marco Guerrini,David G. Fernig,Marcelo A. Lima,Mark A. Skidmore +11 more
TL;DR: The data demonstrate an interaction between the recombinant surface receptor binding domain and the polysaccharide that has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals.
Journal ArticleDOI
Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin.
Courtney J. Mycroft-West,Dunhao Su,Isabel Pagani,Timothy R. Rudd,Stefano Elli,Neha S. Gandhi,Scott E. Guimond,Gavin J. Miller,Maria Cecília Zorél Meneghetti,Helena B. Nader,Yong Li,Quentin M. Nunes,Patricia Procter,Nicasio Mancini,Massimo Clementi,Antonella Bisio,Nicholas R. Forsyth,Vito Ferro,Jeremy E. Turnbull,Marco Guerrini,David G. Fernig,Elisa Vicenzi,Edwin A. Yates,Edwin A. Yates,Marcelo A. Lima,Mark A. Skidmore,Mark A. Skidmore +26 more
TL;DR: In this paper, surface plasmon resonance and circular dichroism spectroscopy were used to investigate the structural basis of heparin and glycosaminoglycan heparan sulfate (HS) binding to the spike protein receptor-binding domain (S1 RBD) of SARS-CoV-2.
Journal ArticleDOI
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
Silvia Ghezzi,Lynsay C. Cooper,Alicia Rubio,Isabel Pagani,Maria Rosaria Capobianchi,Giuseppe Ippolito,Julien Pelletier,Maria Cecília Zorél Meneghetti,Marcelo A. Lima,Mark A. Skidmore,Vania Broccoli,Edwin A. Yates,Edwin A. Yates,Edwin A. Yates,Elisa Vicenzi +14 more
TL;DR: It is shown that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus‐induced cell death of human neural progenitor cells (NPCs).
Posted ContentDOI
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin.
Courtney J. Mycroft-West,Dunhao Su,Isabel Pagani,Timothy R. Rudd,Stefano Elli,Scott E. Guimond,Gavin J. Miller,Maria Cecília Zorél Meneghetti,Helena B. Nader,Yong Li,Quentin M. Nunes,Patricia Procter,Nicasio Mancini,Massimo Clementi,Antonella Bisio,Nicholas R. Forsyth,Jeremy E. Turnbull,Marco Guerrini,David G. Fernig,Elisa Vicenzi,Edwin A. Yates,Edwin A. Yates,Marcelo A. Lima,Mark A. Skidmore,Mark A. Skidmore +24 more
TL;DR: Heparin prevents infection by a range of viruses if added exogenously, including S-associated coronavirus strain HSR1, and inhibits invasion by SARS-CoV-2 and other members of the Coronaviridae.