M
Marcelo Boareto
Researcher at ETH Zurich
Publications - 32
Citations - 2099
Marcelo Boareto is an academic researcher from ETH Zurich. The author has contributed to research in topics: Notch signaling pathway & Neural stem cell. The author has an hindex of 14, co-authored 30 publications receiving 1672 citations. Previous affiliations of Marcelo Boareto include University of São Paulo & Swiss Institute of Bioinformatics.
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Journal ArticleDOI
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
Mohit Kumar Jolly,Marcelo Boareto,Marcelo Boareto,Bin Huang,Dongya Jia,Mingyang Lu,Eshel Ben-Jacob,Eshel Ben-Jacob,José N. Onuchic,Herbert Levine +9 more
TL;DR: The operating principles of the core regulatory network for EMT/MET that acts as a “three-way” switch giving rise to three distinct phenotypes – E, M and hybrid E/M are reviewed and a theoretical framework that can elucidate the role of many other players in regulating epithelial plasticity is presented.
Journal ArticleDOI
Toward understanding cancer stem cell heterogeneity in the tumor microenvironment.
Federico Bocci,Larisa M. Gearhart-Serna,Marcelo Boareto,Mariana Ribeiro,Eshel Ben-Jacob,Gayathri R. Devi,Herbert Levine,José N. Onuchic,Mohit Kumar Jolly +8 more
TL;DR: A mechanism-based dynamical model is shown that the diffusion of EMT-inducing signals such as TGF-β, together with noncell autonomous control of E MT and CSC decision making via the Notch signaling pathway, can explain experimentally observed disparate localization of subsets of CSCs with varying EMT phenotypes in the tumor.
Posted Content
Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
Mohit Kumar Jolly,Marcelo Boareto,Bin Huang,Dongya Jia,Mingyang Lu,José N. Onuchic,Herbert Levine,Eshel Ben-Jacob +7 more
TL;DR: In this article, the operating principles of the core regulatory network for EMT/MET are reviewed, which acts as a three-way switch giving rise to three distinct phenotypes - epithelial, mesenchymal and hybrid epithelial/mesenchymals.
Journal ArticleDOI
Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model
Mohit Kumar Jolly,Dongya Jia,Marcelo Boareto,Marcelo Boareto,Sendurai A. Mani,Kenneth J. Pienta,Eshel Ben-Jacob,Eshel Ben-Jacob,Herbert Levine +8 more
TL;DR: The results unify various apparently contradictory experimental findings regarding the interconnection between EMT and stemness, corroborate the emerging notion that partial EMT associates with stemhood, and offer new testable predictions.
Journal ArticleDOI
Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype.
Marcelo Boareto,Marcelo Boareto,Mohit Kumar Jolly,Mingyang Lu,José N. Onuchic,Cecilia Clementi,Eshel Ben-Jacob,Eshel Ben-Jacob +7 more
TL;DR: It is found that the asymmetry between the modulations of Delta and Jagged leads to the existence of the previously unexplored possibility of a Sender–Receiver phenotype enabling two interacting cells to share a similar fate.