Gayathri R. Devi

TL;DR: This review attempts to summarize the various 3D culture systems, with an emphasis on the most well characterized and widely applied model - multicellular tumor spheroids.

TL;DR: This paper summarizes the advances in the last decade in the field of PTGS using RNA interference approaches and provides relevant comparisons with other oligonucleotide-based approaches with a specific focus on oncology applications.

TL;DR: A mechanism-based dynamical model is shown that the diffusion of EMT-inducing signals such as TGF-β, together with noncell autonomous control of E MT and CSC decision making via the Notch signaling pathway, can explain experimentally observed disparate localization of subsets of CSCs with varying EMT phenotypes in the tumor.

TL;DR: Exercise statistically significantly reduced tumor growth and was associated with a 1.4-fold increase in apoptosis in mice randomly assigned to exercise or sedentary control; exercise plus chemotherapy prolonged growth delay compared with chemotherapy alone (P < .001) in the orthotopic 4T1 model.

TL;DR: Results indicate that IBC tumors are highly redox adapted, which may render them resistant to ROS‐inducing therapies, and DSF, through redox modulation, may be a useful approach to enhance chemo‐ and/or radio‐sensitivity for advanced BC subtypes where therapeutic resistance is an impediment to durable responses to current standard of care.