M
Márcia A. A. Alexandre
Researcher at Federal University of Amazonas
Publications - 29
Citations - 2451
Márcia A. A. Alexandre is an academic researcher from Federal University of Amazonas. The author has contributed to research in topics: Plasmodium vivax & Malaria. The author has an hindex of 18, co-authored 27 publications receiving 2007 citations.
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Journal ArticleDOI
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial.
Mayla Gabriela Silva Borba,Fernando Fonseca Almeida Val,Vanderson de Souza Sampaio,Márcia A. A. Alexandre,Gisely Cardoso de Melo,Marcelo A M Brito,Maria Paula Gomes Mourão,Jose Diego Brito-Sousa,Djane Clarys Baia-da-Silva,Marcus Vinitius de Farias Guerra,Ludhmila Abrahão Hajjar,R. Pinto,Antônio Alcirley da Silva Balieiro,Antonio G. Pacheco,James D. Santos,Felipe Gomes Naveca,Mariana Simão Xavier,André M. Siqueira,Alexandre Vargas Schwarzbold,Julio Croda,Julio Croda,Maurício Lacerda Nogueira,Gustavo Adolfo Sierra Romero,Quique Bassat,Cor Jesus Fernandes Fontes,Bernardino Cláudio de Albuquerque,Cláudio Tadeu Daniel-Ribeiro,Wuelton Marcelo Monteiro,Marcus Lacerda +28 more
TL;DR: The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir.
Journal ArticleDOI
Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With Coronavirus Disease 2019 (COVID-19; Metcovid): A Randomized, Double-blind, Phase IIb, Placebo-controlled Trial.
Christiane Maria Prado Jeronimo,Maria Eduarda Leão de Farias,Fernando Val,Vanderson de Souza Sampaio,Márcia A. A. Alexandre,Gisely Cardoso de Melo,Izabella Picinin Safe,Mayla Gabriela Silva Borba,Rebeca Linhares Abreu Netto,Alex Bezerra Silva Maciel,João Ricardo da Silva Neto,Lucas Barbosa Oliveira,Erick F. G. Figueiredo,Kelry Mazurega Oliveira Dinelly,Maria Gabriela de Almeida Rodrigues,Marcelo A M Brito,Maria Paula Gomes Mourão,Guilherme Augusto Pivoto João,Ludhmila Abrahão Hajjar,Quique Bassat,Gustavo Adolfo Sierra Romero,Felipe Gomes Naveca,Heline Lira Vasconcelos,Michel de Araújo Tavares,Jose Diego Brito-Sousa,Fabio T. M. Costa,Maurício Lacerda Nogueira,Djane Clarys Baia-da-Silva,Mariana Simão Xavier,Wuelton Marcelo Monteiro,Marcus V. G. Lacerda,Metcovid Team +31 more
TL;DR: The findings of this study suggest that a short course of MP in hospitalized patients with COVID-19 did not reduce mortality in the overall population.
Journal ArticleDOI
Severe Plasmodium vivax malaria, Brazilian Amazon.
Márcia A. A. Alexandre,C. Ferreira,André M. Siqueira,Belisa M. L. Magalhães,Maria Paula Gomes Mourão,Marcus V. G. Lacerda,Maria das Graças Costa Alecrim +6 more
TL;DR: A case series of 17 patients hospitalized in Manaus with PCR-confirmed Plasmodium vivax infection who were treated with chloroquine and primaquine were described, and the major complications were jaundice and severe anemia.
Journal ArticleDOI
Postmortem Characterization of Patients With Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent Does This Parasite Kill?
Marcus V. G. Lacerda,Silvio C. P. Fragoso,Maria das Graças Costa Alecrim,Márcia A. A. Alexandre,Belisa M. L. Magalhães,André M. Siqueira,Luiz Carlos de Lima Ferreira,José R. Araújo,Maria Paula Gomes Mourão,M. T. Ferrer,Paola Castillo,Lorena Martin-Jaular,Carmen Fernandez-Becerra,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Ordi,Pedro L. Alonso,Quique Bassat +17 more
TL;DR: In one patient who developed ARDS and presented negative peripheral parasitemia by the time of death, scattered parasitized red blood cells were seen inside pulmonary capillaries, suggesting some sequestration in the lung.
Posted ContentDOI
Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study)
Mayla Gabriela Silva Borba,Fernando Fonseca Almeida Val,Vanderson de Souza Sampaio,Márcia A. A. Alexandre,Gisely Cardoso de Melo,Marcelo A M Brito,Maria Paula Gomes Mourão,Jose Diego Brito-Sousa,Djane Clarys Baia-da-Silva,Marcus Vinitius de Farias Guerra,Ludhmila Abrahão Hajjar,R. Pinto,Antônio Alcirley da Silva Balieiro,Felipe Gomes Naveca,Mariana Simão Xavier,Alexandre Salomão,André M. Siqueira,Alexandre Vargas Schwarzbold,Julio Croda,Maurício Lacerda Nogueira,Gustavo Adolfo Sierra Romero,Quique Bassat,Cor Jesus Fernandes Fontes,Bernardino Cláudio de Albuquerque,Cláudio Tadeu Daniel-Ribeiro,Wuelton Marcelo Monteiro,Marcus Lacerda,CloroCovid Team,Fundação de Vigilância em Saúde do Amazonas. Manaus, Am, Brasil.,Mozambique Centro de Investigação em Saúde de Manhiça. Maputo,Spain Icrea. Barcelona +30 more
TL;DR: Preliminary findings suggest that the higher CQ dosage (10-day regimen) should not be recommended for COVID-19 treatment because of its potential safety hazards.