M
Marcin Cymborowski
Researcher at University of Virginia
Publications - 46
Citations - 3503
Marcin Cymborowski is an academic researcher from University of Virginia. The author has contributed to research in topics: Protein structure & Diffraction. The author has an hindex of 18, co-authored 44 publications receiving 3091 citations. Previous affiliations of Marcin Cymborowski include University of Virginia Health System & Argonne National Laboratory.
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Journal ArticleDOI
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes.
TL;DR: A new approach that integrates data collection, data reduction, phasing and model building significantly accelerates the process of structure determination and on average minimizes the number of data sets and synchrotron time required for structure solution.
Journal ArticleDOI
Double chromodomains cooperate to recognize the methylated histone H3 tail
John F. Flanagan,Li-Zhi Mi,Maksymilian Chruszcz,Marcin Cymborowski,Katrina L. Clines,Youngchang Kim,Wladek Minor,Fraydoon Rastinejad,Sepideh Khorasanizadeh +8 more
TL;DR: It is shown that the human CHD1 double chromodomains target the lysine 4-methylated histone H3 tail (H3K4me), a hallmark of active chromatin, and its interactions with histone tails.
Journal ArticleDOI
In situ proteolysis for protein crystallization and structure determination
Aiping Dong,Xiaohui Xu,Aled M. Edwards,Changsoo Chang,Maksymilian Chruszcz,Marianne Cuff,Marcin Cymborowski,Rosa Di Leo,Olga Egorova,Elena Evdokimova,Ekaterina V. Filippova,Jun Gu,Jennifer L. Guthrie,Alexandr Ignatchenko,Andrzej Joachimiak,Natalie R Klostermann,Youngchang Kim,Yuri Korniyenko,Wladek Minor,Qiuni Que,Alexei Savchenko,Tatiana Skarina,Kemin Tan,Alexander F. Yakunin,Adelinda Yee,Veronica Yim,Rongguang Zhang,Hong Zheng,Masato Akutsu,Cheryl H. Arrowsmith,George V. Avvakumov,Alexey Bochkarev,Lars Göran Dahlgren,Sirano Dhe-Paganon,Slav Dimov,Ludmila Dombrovski,P.J. Finerty,Susanne Flodin,A. Flores,Susanne Gräslund,Martin Hammerström,Maria Dolores Herman,Bum Soo Hong,Raymond Hui,Ida Johansson,Yongson Liu,Martina Nilsson,Lyudmila Nedyalkova,P. Nordlund,Tomas Nyman,Jinrong Min,Hui Ouyang,Hee-Won Park,Chao Qi,Wael M. Rabeh,Limin Shen,Yang Shen,Deepthi Sukumard,Wolfram Tempel,Yufeng Tong,Lionel Tresagues,Masoud Vedadi,John R. Walker,Johan Weigelt,Martin Welin,Hong Wu,Ting Xiao,Hong Zeng,Haizhong Zhu +68 more
TL;DR: The general applicability of in situ proteolysis to form protein crystals suitable for structure determination is tested by adding a protease (chymotrypsin or trypsin) digestion step to crystallization trials of 55 bacterial and 14 human proteins that had proven recalcitrant to best efforts at crystallization or structure determination.
Journal ArticleDOI
The integration of data reduction and structure solution - from diffraction images to an initial model in minutes
Journal ArticleDOI
Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
TL;DR: It is determined that changes in the second coordination sphere affected the enzymatic activity by hydrogen bond rearrangement and substrate positioning through interaction with Gln(495), which demonstrates that the mutations have not affected the mechanism of hydrogen atom tunneling.