Masato Akutsu

TL;DR: Residues of NEMO involved in binding linear ubiquitin chains are required for NF-kappaB activation by TNF-alpha and other agonists, providing an explanation for the detrimental effect of NemO mutations in patients suffering from X-linked ectodermal dysplasia and immunodeficiency.

TL;DR: Severe disruption of Fam134b in mice causes expansion of the ER, inhibits ER turnover, sensitizes cells to stress-induced apoptotic cell death and leads to degeneration of sensory neurons, so selective ER-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans.

TL;DR: Use of Ub chain restriction analysis, in which OTU DUBs are used as restriction enzymes to reveal linkage type and the relative abundance of Ub chains on substrates, reveals that most human OTU enzymes are linkage specific.

TL;DR: An update is provided on the complexity of ubiquitin chains and their physiological relevance and the development of novel technologies has provided detailed insights into the structure and function of previously poorly understood ubiquitIn signals.

TL;DR: It is illustrated that specificity in the interaction between autophagy receptors and Autophagy machinery is of functional importance to execute selective autophagic.