Y
Youngchang Kim
Researcher at Argonne National Laboratory
Publications - 131
Citations - 9264
Youngchang Kim is an academic researcher from Argonne National Laboratory. The author has contributed to research in topics: Protein structure & Binding site. The author has an hindex of 42, co-authored 121 publications receiving 7840 citations. Previous affiliations of Youngchang Kim include Howard Hughes Medical Institute & University of Chicago.
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Journal ArticleDOI
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
Wolfgang Fischle,Yanming Wang,Steven A. Jacobs,Youngchang Kim,C. David Allis,C. David Allis,Sepideh Khorasanizadeh +6 more
TL;DR: It is shown that the chromodomain proteins Polycomb (Pc) and HP1 (heterochromatin protein 1) are highly discriminatory for binding to these sites in vivo and in vitro, and a role for their Chromodomains in both target site binding and discrimination is indicated.
Journal ArticleDOI
Crystal structure of a yeast TBP/TATA-box complex.
TL;DR: The 2.5 Å crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity.
Journal ArticleDOI
Protein production and purification.
Susanne Gräslund,Pär Nordlund,J Weigelt,B M Hallberg,James E. Bray,Opher Gileadi,Stefan Knapp,Udo Oppermann,Cheryl H. Arrowsmith,Raymond Hui,J Ming,Sirano Dhe-Paganon,Park H-W.,Alexei Savchenko,Adelinda Yee,Aled M. Edwards,Renaud Vincentelli,Christian Cambillau,R Kim,Kim S-H.,Zihe Rao,Yunyu Shi,Thomas C. Terwilliger,Kim C-Y.,Hung L-W.,Geoffrey S. Waldo,Yoav Peleg,Shira Albeck,Tamar Unger,Orly Dym,Jaime Prilusky,Joel L. Sussman,Raymond C. Stevens,Scott A. Lesley,Scott A. Lesley,Ian A. Wilson,Ian A. Wilson,Andrzej Joachimiak,Frank R. Collart,Irina Dementieva,Mark I. Donnelly,William H. Eschenfeldt,Youngchang Kim,Lucy Stols,Ruiying Wu,M. Zhou,Stephen K. Burley,J.S. Emtage,J.M. Sauder,D.A. Thompson,Kevin Bain,John G. Luz,Tarun Gheyi,F Zhang,Shane Atwell,Steven C. Almo,Jeffrey B. Bonanno,Andras Fiser,Soumya Swaminathan,F.W. Studier,Mark R. Chance,Andrej Sali,Thomas Acton,Rong Xiao,L Zhao,L C Ma,John F. Hunt,Liang Tong,Kellie Cunningham,Masayori Inouye,Stephen Anderson,Haleema Janjua,Ritu Shastry,C K Ho,D Wang,Hao Wang,M Jiang,Gaetano T. Montelione,David I. Stuart,Raymond J. Owens,S Daenke,Anja Schütz,Udo Heinemann,S Yokoyama,Konrad Büssow,Kristin C. Gunsalus,Kristin C. Gunsalus +86 more
TL;DR: This review presents methods that could be applied at the outset of any project, a prioritized list of alternate strategies and a list of pitfalls that trip many new investigators.
Journal ArticleDOI
Double chromodomains cooperate to recognize the methylated histone H3 tail
John F. Flanagan,Li-Zhi Mi,Maksymilian Chruszcz,Marcin Cymborowski,Katrina L. Clines,Youngchang Kim,Wladek Minor,Fraydoon Rastinejad,Sepideh Khorasanizadeh +8 more
TL;DR: It is shown that the human CHD1 double chromodomains target the lysine 4-methylated histone H3 tail (H3K4me), a hallmark of active chromatin, and its interactions with histone tails.
Journal ArticleDOI
Refinement of Eco RI endonuclease crystal structure: a revised protein chain tracing.
TL;DR: The original model of Eco RI endonuclease proved refractory to crystallographic refinement, whereby model coordinates were adjusted to optimize the fit to the observed diffraction data, and five additional isomorphous derivatives were obtained by cocrystallizing the protein with the halogenated oligonucleotides.