M
Marco Bellinzoni
Researcher at University of Paris
Publications - 60
Citations - 2028
Marco Bellinzoni is an academic researcher from University of Paris. The author has contributed to research in topics: Kinase & Protein phosphorylation. The author has an hindex of 23, co-authored 55 publications receiving 1797 citations. Previous affiliations of Marco Bellinzoni include Centre national de la recherche scientifique & Pasteur Institute.
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Journal ArticleDOI
Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential
Annemarie Wehenkel,Marco Bellinzoni,Martín Graña,Rosario Durán,Andrea Villarino,Pablo Fernandez,Gwenaëlle André-Leroux,Patrick England,Howard Takiff,Carlos Cerveñansky,Stewart T. Cole,Pedro M. Alzari +11 more
TL;DR: The current knowledge on Ser/Thr protein kinases and phosphatases in M. tuberculosis is reviewed, their regulation mechanisms and putative substrates are explored, and their therapeutic potential as possible targets for the development of new anti-mycobacterial compounds are explored.
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Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis
Maria Rosalia Pasca,Paola Guglierame,Fabio Arcesi,Marco Bellinzoni,Edda De Rossi,Giovanna Riccardi +5 more
TL;DR: The Mycobacterium tuberculosis Rv2686c-Rv2687c-rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxACin, moxifloxacIn, and sparfloxAcin to Myc Cobacterium smegmatis.
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Regulation of glutamate metabolism by protein kinases in mycobacteria
Helen M. O'Hare,Rosario Durán,Carlos Cerveñansky,Marco Bellinzoni,Anne Marie Wehenkel,Otto Pritsch,Gonzalo Obal,Jens Baumgartner,Jérôme Vialaret,Kai Johnsson,Pedro M. Alzari +10 more
TL;DR: It is shown that protein kinase G of Mycobacterium tuberculosis undergoes a pattern of autophosphorylation that is distinct from that of other M.’tuberculosis protein kinases characterized to date and GarA is identified as a substrate for phosphorylation by PknG, which may contribute to the attenuation of virulence.
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The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.
Edda De Rossi,Patrizio Arrigo,Marco Bellinzoni,Pedro E. A. Silva,Carlos Martin,José A. Aínsa,Paola Guglierame,Giovanna Riccardi +7 more
TL;DR: The inventory of the drug transporters subfamily, included in the major facilitator superfamily (MFS), encoded by the complete genome of Mycobacterium tuberculosis, revealed 16 open reading frames encoding putative drug efflux pumps belonging to MFS, and it is demonstrated that two of them function asDrug efflux proteins.
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The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria
Annemarie Wehenkel,Pablo Fernandez,Marco Bellinzoni,Vincent Catherinot,Nathalie Barilone,Gilles Labesse,Mary Jackson,Pedro M. Alzari +7 more
TL;DR: It is demonstrated that mitoxantrone, an anthraquinone derivative used in cancer therapy, is a PknB inhibitor capable of preventing mycobacterial growth.