M
Marcus Maldonado
Researcher at University of California, San Diego
Publications - 7
Citations - 507
Marcus Maldonado is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Carcinogenesis & Centrosome. The author has an hindex of 5, co-authored 7 publications receiving 353 citations. Previous affiliations of Marcus Maldonado include Ludwig Institute for Cancer Research.
Papers
More filters
Journal ArticleDOI
Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
Shahram Saberi,Jennifer E. Stauffer,Jie Jiang,Jie Jiang,Sandra Diaz Garcia,Amy Taylor,Derek Schulte,Takuya Ohkubo,Cheyenne L Schloffman,Marcus Maldonado,Michael Baughn,María Jesús Delgado Rodríguez,Donald P. Pizzo,Don W. Cleveland,Don W. Cleveland,John Ravits +15 more
TL;DR: In this article, the authors quantitatively studied and compared dipeptide repeat proteins (DPRs) poly-GP, polyGA, poly-GR, polyGR poly-PR and poly-PA in clinically related and clinically unrelated regions of the central nervous system.
Journal Article
Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat expanded C9orf72 amyotrophic lateral sclerosis (P3.031)
Shahram Saberi,Jennifer E. Stauffer,Jie Jiang,Sandra N. Garcia,Derek Schulte,Takuya Ohkubo,Cheyenne Schloffman,Marcus Maldonado,Michael Baughn,Maria Rodriquez,Donald P. Pizzo,Don W. Cleveland,John Ravits +12 more
TL;DR: In this article, the authors quantitatively studied and compared dipeptide repeat proteins (DPRs) in clinically-related and clinically-unrelated regions of the central nervous system, and compared them to phosphorylated TDP-43, the hallmark protein of ALS.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1
Adrian Israelson,Dara Ditsworth,Shuying Sun,SungWon Song,SungWon Song,Jason Liang,Marian Hruska-Plochan,Melissa McAlonis-Downes,Salah Abu-Hamad,Guy Zoltsman,Tom Shani,Marcus Maldonado,Anh Bui,Michael Navarro,Huilin Zhou,Martin Marsala,Brian K. Kaspar,Brian K. Kaspar,Sandrine Da Cruz,Don W. Cleveland +19 more
TL;DR: Accumulated MIF protein is identified to be low in motor neurons, implicating correspondingly low chaperone activity as a component of vulnerability to mutant SOD1 misfolding and supporting therapies to enhance intracellular MIF chaper one activity.
Journal ArticleDOI
Chronic centrosome amplification without tumorigenesis
Benjamin Vitre,Andrew J. Holland,Anita Kulukian,Ofer Shoshani,Maretoshi Hirai,Yin Wang,Marcus Maldonado,Thomas Cho,Jihane Boubaker,Deborah A. Swing,Lino Tessarollo,Sylvia M. Evans,Elaine Fuchs,Don W. Cleveland,Don W. Cleveland +14 more
TL;DR: It is concluded that, independent of p53 status, supernumerary centrosomes are not sufficient to drive tumor formation.
Journal ArticleDOI
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.
Dara Ditsworth,Marcus Maldonado,Melissa McAlonis-Downes,Shuying Sun,Shuying Sun,Amanda Seelman,Kevin Drenner,Eveline S. Arnold,Shuo-Chien Ling,Shuo-Chien Ling,Donald P. Pizzo,John Ravits,Don W. Cleveland,Sandrine Da Cruz +13 more
TL;DR: Reduction of mutant TDP-43 selectively in motor neurons did not prevent age-dependent degeneration of axons and neuromuscular junction loss, nor did it attenuate astrogliosis or microgliosis.