J
Jie Jiang
Researcher at Emory University
Publications - 47
Citations - 4281
Jie Jiang is an academic researcher from Emory University. The author has contributed to research in topics: C9orf72 & Trinucleotide repeat expansion. The author has an hindex of 23, co-authored 41 publications receiving 3489 citations. Previous affiliations of Jie Jiang include University of California, San Diego & King's College London.
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Journal ArticleDOI
Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR
TL;DR: GAPDH was found to be the most suitable housekeeping gene for expression studies in reticulocytes while the commonly used B2M should be avoided.
Journal ArticleDOI
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
Clotilde Lagier-Tourenne,Michael Baughn,Frank Rigo,Shuying Sun,Patrick Liu,Hairi Li,Jie Jiang,Andrew T. Watt,Seung J. Chun,Melanie Katz,Jinsong Qiu,Ying Sun,Shuo-Chien Ling,Qiang Zhu,Magdalini Polymenidou,Kevin Drenner,Jonathan W. Artates,Melissa McAlonis-Downes,Sebastian Markmiller,Kasey R. Hutt,Donald P. Pizzo,Janet Cady,Matthew B. Harms,Robert H. Baloh,Scott R. VandenBerg,Gene W. Yeo,Xiang-Dong Fu,C. Frank Bennett,Don W. Cleveland,John Ravits +29 more
TL;DR: Sustained ASO-mediated lowering of C9orf72 RNAs throughout the CNS of mice is demonstrated to be well tolerated, producing no behavioral or pathological features characteristic of ALS/FTD and only limited RNA expression alterations.
Journal ArticleDOI
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
Jie Jiang,Jie Jiang,Qiang Zhu,Tania F. Gendron,Shahram Saberi,Melissa McAlonis-Downes,Amanda Seelman,Jennifer E. Stauffer,Paymaan Jafar-Nejad,Kevin Drenner,Derek Schulte,Seung J. Chun,Shuying Sun,Shuo-Chien Ling,Shuo-Chien Ling,Brian Myers,Jeffery Engelhardt,Melanie Katz,Michael Baughn,Michael Baughn,Oleksandr Platoshyn,Oleksandr Platoshyn,Martin Marsala,Martin Marsala,Martin Marsala,Andrew T. Watt,Charles J. Heyser,M. Colin Ard,Louis De Muynck,Lillian M. Daughrity,Deborah A. Swing,Lino Tessarollo,Chris J. Jung,Arnaud Delpoux,Daniel T. Utzschneider,Stephen M. Hedrick,Pieter J. de Jong,Dieter Edbauer,Philip Van Damme,Leonard Petrucelli,Christopher Shaw,C. Frank Bennett,Sandrine Da Cruz,John Ravits,Frank Rigo,Don W. Cleveland,Don W. Cleveland,Clotilde Lagier-Tourenne,Clotilde Lagier-Tourenne +48 more
TL;DR: Single-dose injection of antisense oligonucleotides (ASOs) that target repeat-containing RNAs but preserve levels of mRNAs encoding C9ORF72 produced sustained reductions in RNA foci and dipeptide-repeat proteins, and ameliorated behavioral deficits.
Journal ArticleDOI
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
Yong Jie Zhang,Tania F. Gendron,Jonathan C. Grima,Hiroki Sasaguri,Karen Jansen-West,Ya Fei Xu,Rebecca B. Katzman,Jennifer Gass,Melissa E. Murray,Mitsuru Shinohara,Wen Lang Lin,Aliesha Garrett,Jeannette N. Stankowski,Lillian M. Daughrity,Jimei Tong,Emilie A. Perkerson,Mei Yue,Jeannie Chew,Monica Castanedes-Casey,Aishe Kurti,Zizhao S. Wang,Amanda M. Liesinger,Jeremy D. Baker,Jie Jiang,Clotilde Lagier-Tourenne,Dieter Edbauer,Dieter Edbauer,Don W. Cleveland,Rosa Rademakers,Kevin B. Boylan,Guojun Bu,Christopher D. Link,Chad A. Dickey,Jeffrey D. Rothstein,Dennis W. Dickson,John D. Fryer,Leonard Petrucelli +36 more
TL;DR: It is demonstrated that sequestration and impairment of nuclear HR23 and nucleocytoplasmic transport proteins is an outcome of, and a contributor to, poly(GA) pathology.
Journal Article
cMYB is involved in the regulation of fetal hemoglobin production in adults. Commentary
Susan P. Perrine,Jie Jiang,Steve Best,Stephan Menzel,Nicholas Silver,Mei I Lai,Gabriela L. Surdulescu,Tim D. Spector,Swee Lay Thein +8 more
TL;DR: In this article, a quantitative trait locus (QTL) controlling HbF levels has been mapped to chromosome 6q23 in an Asian-Indian kindred with β thalassemia and heterocellular hereditary persistence of fetal hemoglobin (HPFH).