S
Shuying Sun
Researcher at Johns Hopkins University School of Medicine
Publications - 31
Citations - 4046
Shuying Sun is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: RNA splicing & Exon. The author has an hindex of 19, co-authored 24 publications receiving 3413 citations. Previous affiliations of Shuying Sun include Cold Spring Harbor Laboratory & University of California, San Diego.
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Journal ArticleDOI
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
Ana Jovičić,Jerome Mertens,Steven Boeynaems,Steven Boeynaems,Elke Bogaert,Elke Bogaert,Noori Chai,Shizuka B. Yamada,Joseph W. Paul,Shuying Sun,Joseph R. Herdy,Gregor Bieri,Nicholas J. Kramer,Fred H. Gage,Ludo Van Den Bosch,Ludo Van Den Bosch,Wim Robberecht,Wim Robberecht,Aaron D. Gitler +18 more
TL;DR: Two unbiased screens in Saccharomyces cerevisiae were performed and potent modifiers of DPR toxicity, including karyopherins and effectors of Ran-mediated nucleocytoplasmic transport were identified, providing insight into potential disease mechanisms and therapeutic targets.
Journal ArticleDOI
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
Clotilde Lagier-Tourenne,Michael Baughn,Frank Rigo,Shuying Sun,Patrick Liu,Hairi Li,Jie Jiang,Andrew T. Watt,Seung J. Chun,Melanie Katz,Jinsong Qiu,Ying Sun,Shuo-Chien Ling,Qiang Zhu,Magdalini Polymenidou,Kevin Drenner,Jonathan W. Artates,Melissa McAlonis-Downes,Sebastian Markmiller,Kasey R. Hutt,Donald P. Pizzo,Janet Cady,Matthew B. Harms,Robert H. Baloh,Scott R. VandenBerg,Gene W. Yeo,Xiang-Dong Fu,C. Frank Bennett,Don W. Cleveland,John Ravits +29 more
TL;DR: Sustained ASO-mediated lowering of C9orf72 RNAs throughout the CNS of mice is demonstrated to be well tolerated, producing no behavioral or pathological features characteristic of ALS/FTD and only limited RNA expression alterations.
Journal ArticleDOI
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
Jie Jiang,Jie Jiang,Qiang Zhu,Tania F. Gendron,Shahram Saberi,Melissa McAlonis-Downes,Amanda Seelman,Jennifer E. Stauffer,Paymaan Jafar-Nejad,Kevin Drenner,Derek Schulte,Seung J. Chun,Shuying Sun,Shuo-Chien Ling,Shuo-Chien Ling,Brian Myers,Jeffery Engelhardt,Melanie Katz,Michael Baughn,Michael Baughn,Oleksandr Platoshyn,Oleksandr Platoshyn,Martin Marsala,Martin Marsala,Martin Marsala,Andrew T. Watt,Charles J. Heyser,M. Colin Ard,Louis De Muynck,Lillian M. Daughrity,Deborah A. Swing,Lino Tessarollo,Chris J. Jung,Arnaud Delpoux,Daniel T. Utzschneider,Stephen M. Hedrick,Pieter J. de Jong,Dieter Edbauer,Philip Van Damme,Leonard Petrucelli,Christopher Shaw,C. Frank Bennett,Sandrine Da Cruz,John Ravits,Frank Rigo,Don W. Cleveland,Don W. Cleveland,Clotilde Lagier-Tourenne,Clotilde Lagier-Tourenne +48 more
TL;DR: Single-dose injection of antisense oligonucleotides (ASOs) that target repeat-containing RNAs but preserve levels of mRNAs encoding C9ORF72 produced sustained reductions in RNA foci and dipeptide-repeat proteins, and ameliorated behavioral deficits.
Journal ArticleDOI
HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism
Sebastien M. Weyn-Vanhentenryck,Aldo Mele,Qinghong Yan,Shuying Sun,Shuying Sun,Natalie G. Farny,Zuo Zhang,Zuo Zhang,Chenghai Xue,Margaret Herre,Pamela A. Silver,Michael Q. Zhang,Michael Q. Zhang,Adrian R. Krainer,Robert B. Darnell,Chaolin Zhang +15 more
TL;DR: Al Alteration of Rb fox targets in some autistic brains is correlated with downregulation of all three Rbfox proteins, supporting the potential clinical relevance of the splicing-regulatory network.
Journal ArticleDOI
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2
Chaolin Zhang,Zuo Zhang,John C. Castle,Shuying Sun,Shuying Sun,Jason M. Johnson,Adrian R. Krainer,Michael Q. Zhang +7 more
TL;DR: The authors comprehensively predict the targets of the brain and muscle-specific splicing factor Fox-1 (A2BP1) and its paralog Fox-2 (RBM9) and systematically define the corresponding splicing regulatory networks genome-wide.