M
Michael Baughn
Researcher at University of California, San Diego
Publications - 18
Citations - 3245
Michael Baughn is an academic researcher from University of California, San Diego. The author has contributed to research in topics: C9orf72 & C9orf72 Protein. The author has an hindex of 14, co-authored 15 publications receiving 2680 citations. Previous affiliations of Michael Baughn include Ludwig Institute for Cancer Research & Benaroya Research Institute.
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Journal ArticleDOI
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
Clotilde Lagier-Tourenne,Magdalini Polymenidou,Kasey R. Hutt,Anthony Q. Vu,Michael Baughn,Stephanie C. Huelga,Kevin M. Clutario,Shuo-Chien Ling,Tiffany Y. Liang,Curt Mazur,Edward Wancewicz,Aneeza Kim,Andrew T. Watt,Sue Freier,Geoffrey G. Hicks,John Paul Donohue,Lily Shiue,C. Frank Bennett,John Ravits,Don W. Cleveland,Gene W. Yeo,Gene W. Yeo +21 more
TL;DR: Depletion of FUS/TLS from the adult nervous system altered the levels or splicing of >950 mRNAs, most of which are distinct from RNAs dependent on TDP-43, supporting a common loss-of-function pathway as one component underlying motor neuron death from misregulation of T DP-43 or FUS-43.
Journal ArticleDOI
Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
Dhruv Sareen,Jacqueline G. O’Rourke,Pratap Meera,A. K. M. G. Muhammad,Sharday Grant,Megan Simpkinson,Shaughn Bell,Sharon Carmona,Loren Ornelas,Anais Sahabian,Tania F. Gendron,Leonard Petrucelli,Michael Baughn,John Ravits,Matthew B. Harms,Frank Rigo,C. Frank Bennett,Thomas S. Otis,Clive N. Svendsen,Robert H. Baloh +19 more
TL;DR: Findings support the idea that the buildup of “toxic” RNA containing the GGGGCC repeat contributes to the death of motor neurons in ALS, and suggest that antisense oligonucleotides targeting this transcript may be a strategy for treating ALS patients with the C9ORF72 repeat expansion.
Journal ArticleDOI
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
Clotilde Lagier-Tourenne,Michael Baughn,Frank Rigo,Shuying Sun,Patrick Liu,Hairi Li,Jie Jiang,Andrew T. Watt,Seung J. Chun,Melanie Katz,Jinsong Qiu,Ying Sun,Shuo-Chien Ling,Qiang Zhu,Magdalini Polymenidou,Kevin Drenner,Jonathan W. Artates,Melissa McAlonis-Downes,Sebastian Markmiller,Kasey R. Hutt,Donald P. Pizzo,Janet Cady,Matthew B. Harms,Robert H. Baloh,Scott R. VandenBerg,Gene W. Yeo,Xiang-Dong Fu,C. Frank Bennett,Don W. Cleveland,John Ravits +29 more
TL;DR: Sustained ASO-mediated lowering of C9orf72 RNAs throughout the CNS of mice is demonstrated to be well tolerated, producing no behavioral or pathological features characteristic of ALS/FTD and only limited RNA expression alterations.
Journal ArticleDOI
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
Jie Jiang,Jie Jiang,Qiang Zhu,Tania F. Gendron,Shahram Saberi,Melissa McAlonis-Downes,Amanda Seelman,Jennifer E. Stauffer,Paymaan Jafar-Nejad,Kevin Drenner,Derek Schulte,Seung J. Chun,Shuying Sun,Shuo-Chien Ling,Shuo-Chien Ling,Brian Myers,Jeffery Engelhardt,Melanie Katz,Michael Baughn,Michael Baughn,Oleksandr Platoshyn,Oleksandr Platoshyn,Martin Marsala,Martin Marsala,Martin Marsala,Andrew T. Watt,Charles J. Heyser,M. Colin Ard,Louis De Muynck,Lillian M. Daughrity,Deborah A. Swing,Lino Tessarollo,Chris J. Jung,Arnaud Delpoux,Daniel T. Utzschneider,Stephen M. Hedrick,Pieter J. de Jong,Dieter Edbauer,Philip Van Damme,Leonard Petrucelli,Christopher Shaw,C. Frank Bennett,Sandrine Da Cruz,John Ravits,Frank Rigo,Don W. Cleveland,Don W. Cleveland,Clotilde Lagier-Tourenne,Clotilde Lagier-Tourenne +48 more
TL;DR: Single-dose injection of antisense oligonucleotides (ASOs) that target repeat-containing RNAs but preserve levels of mRNAs encoding C9ORF72 produced sustained reductions in RNA foci and dipeptide-repeat proteins, and ameliorated behavioral deficits.
Journal ArticleDOI
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.
Ze’ev Melamed,Jone López-Erauskin,Michael Baughn,Ouyang Zhang,Kevin Drenner,Ying Sun,Fernande Freyermuth,Moira A. McMahon,Melinda S. Beccari,Jon Artates,Takuya Ohkubo,María José Cubillas Rodríguez,Nianwei Lin,Dongmei Wu,C. Frank Bennett,Frank Rigo,Sandrine Da Cruz,John Ravits,Clotilde Lagier-Tourenne,Don W. Cleveland +19 more
TL;DR: Reduction in TDP-43 is shown to inhibit axonal regeneration of iPSC-derived motor neurons, and rescue of stathmin-2 expression restores axonal regenerative capacity, a hallmark of ALS–FTD that functionally links reduced nuclear TSP function to enhanced neuronal vulnerability.