G
Geert-Jan van Gemert
Researcher at Radboud University Nijmegen
Publications - 114
Citations - 7691
Geert-Jan van Gemert is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 44, co-authored 98 publications receiving 6636 citations. Previous affiliations of Geert-Jan van Gemert include Utrecht University & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Protection against a Malaria Challenge by Sporozoite Inoculation
Meta Roestenberg,Matthew B. B. McCall,Joost Hopman,Jorien Wiersma,Adrian J. F. Luty,Geert-Jan van Gemert,Marga van de Vegte-Bolmer,Ben C. L. van Schaijk,Karina Teelen,Theo Arens,Lopke Spaarman,Quirijn de Mast,Will Roeffen,Georges Snounou,Laurent Rénia,André J. A. M. van der Ven,Cornelus C. Hermsen,Robert W. Sauerwein +17 more
TL;DR: The induction of parasite-specific pluripotent effector memory T cells producing interferon-gamma, tumor necrosis factor alpha, and interleukin-2 as a promising immunologic marker of protection against a homologous malaria challenge can be induced by the inoculation of intact sporozoites.
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High efficiency transfection of Plasmodium berghei facilitates novel selection procedures.
Chris J. Janse,Blandine Franke-Fayard,Gunnar R. Mair,Jai Ramesar,Corinna Thiel,Sabine Engelmann,Kai Matuschewski,Geert-Jan van Gemert,Robert W. Sauerwein,Andrew P. Waters +9 more
TL;DR: The combination of enhanced transfection efficiency and a versatile rodent model provides a basis for the further development of novel tools for high throughput genome manipulation.
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A central role for P48/45 in malaria parasite male gamete fertility.
Melissa R. van Dijk,Chris J. Janse,Joanne Thompson,Andrew P. Waters,Joanna A. M. Braks,Huub J. Dodemont,Henk Stunnenberg,Geert-Jan van Gemert,Robert W. Sauerwein,Wijnand Eling +9 more
TL;DR: P48/45 is shown to be a surface protein of malaria parasites with a demonstrable role in fertilization and only male gamete fertility of p48/ 45- parasites was affected, failing to penetrate otherwise fertile female gametes.
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A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.
Olivier Silvie,Jean-François Franetich,Stéphanie Charrin,Markus S. Mueller,Anthony Siau,Myriam Bodescot,Eric Rubinstein,Laurent Hannoun,Yupin Charoenvit,Clemens H. M. Kocken,Alan W. Thomas,Geert-Jan van Gemert,Robert W. Sauerwein,Michael J. Blackman,Robin F. Anders,Gerd Pluschke,Dominique Mazier +16 more
TL;DR: Investigation of the expression and function of another microneme protein recently identified in Plasmodium falciparum sporozoites, apical membrane antigen 1 (AMA-1), finds that interfering with sporozoite proteolytic processing may constitute a valuable strategy to prevent hepatocyte infection.
Journal ArticleDOI
Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells
Melissa R. van Dijk,Bruno Douradinha,Blandine Franke-Fayard,Volker Heussler,Maaike W. van Dooren,Ben C. L. van Schaijk,Geert-Jan van Gemert,Robert W. Sauerwein,Maria M. Mota,Andrew P. Waters,Chris J. Janse +10 more
TL;DR: Analysis of sporozoites of Plasmodium berghei that are deficient in P36p (p36p(-)), a member of the P48/45 family of surface proteins, demonstrates that liver cells infected with p36P(-) sporozoite disappear rapidly as a result of apoptosis of host cells that may potentiate the immune response.