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Margret Barbara Basinski
Researcher at Eli Lilly and Company
Publications - 10
Citations - 2317
Margret Barbara Basinski is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Nucleic acid & Adipose tissue. The author has an hindex of 6, co-authored 10 publications receiving 2281 citations.
Papers
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Journal ArticleDOI
The role of neuropeptide Y in the antiobesity action of the obese gene product.
Thomas W. Stephens,Margret Barbara Basinski,P K Bristow,Julie M Bue-Valleskey,S G Burgett,L Craft,John E. Hale,Jules A. Hoffmann,Hansen M. Hsiung,Aidas Kriauciunas +9 more
TL;DR: In this paper, a truncated inactive protein was found to suppress food intake and decrease body weight in normal and ob/ob mice but not db/db (diabetic) mice, which are thought to lack the appropriate receptor.
Journal ArticleDOI
Crystal structure of the obese protein leptin-E100.
Faming Zhang,Margret Barbara Basinski,John Michael Beals,Stephen L. Briggs,Lisa M. Churgay,David K. Clawson,Richard D. DiMarchi,Thomas Charles Furman,John E. Hale,Hansen M. Hsiung,Brigitte Elisabeth Schoner,Dennis P. Smith,Xing Y. Zhang,Jean-Pierre Wery,Richard Walter Schevitz +14 more
TL;DR: The crystal structure at 2.4 Å resolution of a human mutant OB protein (leptin-E100) is reported that has comparable biological activity to wild type but which crystallizes more readily and reveals a four-helix bundle similar to that of the long-chain helical cytokine family.
Patent
Rhesus ob protein and dna
TL;DR: In this paper, the Rhesus ob gene and gene product are disclosed, along with proteins, pharmaceutical formulations, and methods useful for expressing proteins that regulate the body's volume of adipose tissues.
Patent
Human obesity gene
TL;DR: In this paper, isolated DNA molecules that encode two different forms of the human ob gene product which regulate obesity in mammals, especially humans, were described and preferred embodiments of the native DNA encoding these two protein forms are disclosed.
Patent
Method for measuring nucleic acids
Margret Barbara Basinski,Steven D. Kahl,Anne Elizabeth Reifel-Miller,Brigitte Elisabeth Schoner,Sitta Sittampalam +4 more
TL;DR: In this paper, methods for using peptide nucleic acid (PNA) and/or deoxy nucleotide guanidine (DNG) derivatives as probes to quantify specific RNA or DNA sequences, especially those associated with gene function.