Maria Angeles Mena

TL;DR: Treatment strategies that provide more continuous stimulation of dopamine receptors provide reduced motor complications in MPTP monkeys and PD patients and studies raise the possibility that more continuous and physiological delivery of levodopa might reduce the risk of motor complications.

TL;DR: In this paper, Parkin knockout (PK-KO) mice were treated with rotenone (ROT) to induce a selective reduction of tyrosine hydroxylase-immunoreactive cells and other neurons.

TL;DR: The damage of DA neurons took place before the rising of quinones, suggesting thatQuinones are not essential in L-DOPA toxicity for DA neurons, and antioxidants completely prevented L- DOPA-induced quinone formation as well as the death of non-DA neurons.

TL;DR: Trehalose is a powerful modifier of abnormal protein accumulation in neurodegenerative diseases and inhibition of autophagy reverted the neuroprotective effects of trehalose in epoxomicin-induced cell death.

TL;DR: The protective effect against L-DOPA neurotoxicity by glia conditioned medium is mediated by several compounds including neurotrophic factors and small antioxidants and is more effective than the fraction of larger molecular size, that contains large neurotrophic peptides.