P
Patrick H. O'Farrell
Researcher at University of California, San Francisco
Publications - 151
Citations - 39639
Patrick H. O'Farrell is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cyclin A & Gene. The author has an hindex of 69, co-authored 145 publications receiving 38814 citations. Previous affiliations of Patrick H. O'Farrell include Genentech & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
High resolution two-dimensional electrophoresis of proteins.
TL;DR: This technique provides a method for estimation of the number of proteins made by any biological system and can resolve proteins differing in a single charge and consequently can be used in the analysis of in vivo modifications resulting in a change in charge.
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High resolution two-dimensional electrophoresis of basic as well as acidic proteins
TL;DR: This paper describes an alternate procedure for the first dimension which, unlike isoelectric focusing, resolves basic as well as acidic proteins, and involves a short time of electrophoresis toward the cathode and separates most proteins according to their isoelection points.
Journal ArticleDOI
Comparative Genomics of the Eukaryotes
Gerald M. Rubin,Mark Yandell,Jennifer R. Wortman,George L. Gabor,Miklos,Catherine R. Nelson,Iswar K. Hariharan,Mark E. Fortini,Peter W. Li,Rolf Apweiler,Wolfgang Fleischmann,J. Michael Cherry,Steven Henikoff,Marian P. Skupski,Sima Misra,Michael Ashburner,Ewan Birney,Mark S. Boguski,Thomas Brody,Peter Brokstein,Susan E. Celniker,Stephen A. Chervitz,David Coates,Anibal Cravchik,Andrei Gabrielian,Richard F. Galle,William M. Gelbart,Reed A. George,Lawrence S.B. Goldstein,Fangcheng Gong,Ping Guan,Nomi L. Harris,Bruce A. Hay,Roger A. Hoskins,Jiayin Li,Zhenya Li,Richard O. Hynes,Steven J.M. Jones,Peter M. Kuehl,Bruno Lemaitre,J. Troy Littleton,Deborah K. Morrison,Christopher J. Mungall,Patrick H. O'Farrell,Oxana K. Pickeral,Chris Shue,Leslie B. Vosshall,Jiong Zhang,Qi Zhao,Xiangqun H. Zheng,Fei Zhong,Wenyan Zhong,Richard A. Gibbs,J. Craig Venter,Mark Raymond Adams,Suzanna E. Lewis +55 more
TL;DR: The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
Journal ArticleDOI
Genetic control of cell division patterns in the Drosophila embryo
TL;DR: The cloning of stg is described, and it is shown that its predicted amino acid sequence is homologous to that of cdc25, a regular of mitotic initiation in the yeast S. pombe, suggesting that regulated expression of stG mRNA controls the timing and location of these embryonic cell divisions.
Journal ArticleDOI
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
Maria-Carla Saleh,Ronald P. van Rij,Armin Hekele,Amethyst Gillis,Edan Foley,Edan Foley,Patrick H. O'Farrell,Raul Andino +7 more
TL;DR: The pathway for dsRNA uptake in Drosophila melanogaster S2 cells is identified and appears to be evolutionarily conserved, as knockdown of orthologues in Caenorhabditis elegans inactivated the RNA interference response in worms.