M
Maria Donata Benedetti
Researcher at University of Verona
Publications - 54
Citations - 1570
Maria Donata Benedetti is an academic researcher from University of Verona. The author has contributed to research in topics: Multiple sclerosis & Population. The author has an hindex of 19, co-authored 53 publications receiving 1262 citations.
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Inflammatory intrathecal profiles and cortical damage in multiple sclerosis
Roberta Magliozzi,Roberta Magliozzi,Owain W. Howell,Richard Nicholas,Carolina Cruciani,Carolina Cruciani,Marco Castellaro,Chiara Romualdi,Stefania Rossi,Marco Pitteri,Maria Donata Benedetti,Alberto Gajofatto,Francesca B. Pizzini,Stefania Montemezzi,Sarah Rasia,Ruggero Capra,Alessandra Bertoldo,Francesco Facchiano,Salvatore Monaco,Richard Reynolds,Massimiliano Calabrese +20 more
TL;DR: Gray matter damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in multiple sclerosis, but can these changes be identified in the patient early in the disease course?
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Treatment strategies for multiple sclerosis: When to start, when to change, when to stop?
TL;DR: The present review is aimed at critically describing current treatment strategies for MS with a particular focus on the decision of starting, switching and stopping commercially available immunomodulatory and immunosuppressive therapies.
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Clinical spectrum and IgG subclass analysis of anti-myelin oligodendrocyte glycoprotein antibody-associated syndromes: a multicenter study.
Sara Mariotto,Sara Mariotto,Sergio Ferrari,Salvatore Monaco,Maria Donata Benedetti,Kathrin Schanda,Daniela Alberti,Alessia Farinazzo,Ruggero Capra,Chiara Rosa Mancinelli,Nicola De Rossi,Roberto Bombardi,Luigi Zuliani,Marco Zoccarato,Raffaella Tanel,Adriana Bonora,Marco Turatti,Massimiliano Calabrese,Alberto Polo,Antonino Pavone,Luisa Grazian,GianPietro Sechi,Elia Sechi,Daniele Urso,Rachele Delogu,Francesco Janes,Luciano Deotto,Morena Cadaldini,Maria Rachele Bianchi,Gaetano Cantalupo,Markus Reindl,Alberto Gajofatto +31 more
TL;DR: It is confirmed that MOG-Ab-related syndromes have distinct features in the spectrum of demyelinating conditions, and the possible role of the different IgG subclasses in this condition is described.
Journal ArticleDOI
Genetic Association and Altered Gene Expression of Mir-155 in Multiple Sclerosis Patients
Elvezia Maria Paraboschi,Giulia Soldà,Donato Gemmati,Elisa Orioli,Giulia Zeri,Maria Donata Benedetti,Alessandro Salviati,Nadia Barizzone,Maurizio Leone,Stefano Duga,Rosanna Asselta +10 more
TL;DR: Monitoring the differential expression of 22 immunity-related miRNAs in peripheral blood mononuclear cells of MS patients and healthy controls, by using a microbead-based technology found the most up-regulated miRNA (mir-155) was previously reported to be up- regulated also in MS brain lesions and confirmed by qPCR experiments.
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Increased cortical lesion load and intrathecal inflammation is associated with oligoclonal bands in multiple sclerosis patients: a combined CSF and MRI study.
Gabriele Farina,Gabriele Farina,Roberta Magliozzi,Roberta Magliozzi,Marco Pitteri,Richard Reynolds,Stefania Rossi,Stefania Rossi,Alberto Gajofatto,Maria Donata Benedetti,Francesco Facchiano,Salvatore Monaco,Massimiliano Calabrese +12 more
TL;DR: OCB at MS onset are associated with more severe GM pathology and with a more severe physical disability and cognitive impairment after 10 years, and increased levels of cytokines linked to B cell activation, lymphoid-neogenesis, and pro-inflammatory immune response in the CSF of OCB+ patients support the hypothesis of crucial role played by compartmentalized, intrathecal B cell response inThe pathogenesis of CLs and OCB production.