Maria Drobnjak

TL;DR: Overexpression of this bone metastasis gene set is superimposed on a poor-prognosis gene expression signature already present in the parental breast cancer population, suggesting that metastasis requires a set of functions beyond those underlying the emergence of the primary tumor.

TL;DR: It is demonstrated that, at a tolerable dose, inhibition of Hsp90 function by 17-AAG results in a marked reduction in HER2, AR, and Akt expression and inhibition of prostate tumor growth in mice, suggesting that this drug may represent a new strategy for the treatment of prostate cancer.

TL;DR: Study of superficial transitional cell carcinomas of the urinary bladder by immunohistochemical analysis suggests that alterations of p53 and pRB have a cooperative negative effect on both progression and survival in primary bladder cancer.

TL;DR: HDRM2 overexpression appears to be an independent predictor of survival for patients with primary melanoma; however, larger prospective studies are required for validation.

TL;DR: The findings indicate the importance of a comprehensive genetic assessment of bi‐allelic alterations in the HR pathway to deliver a precision medicine‐based approach to select patients for therapies targeting tumour‐specific DNA repair defects.