María E. Casado

TL;DR: The effects of atypical or second-generation antipsychotics (SGA), such as clozapine, risperidone, and ziprasid one, on intracellular lipid metabolism in different cell lines are investigated, finding that these effects of SGAs on lipid homeostasis may be relevant in the metabolic side effects of antippsychotics, especially hypertriglyceridemia.

TL;DR: In glioma and oligodendroglioma cells, it is demonstrated that urolithins, the ellagic acid metabolites that circulate in plasma, stimulate the synthesis of ceramide within the brain, which suggests thatEllagic acid consumption protects against demyelination in rats with induced EAE, likely by a mechanism involving sphingolipid synthesis.

TL;DR: HSL knockout male mice have increased expression of class B scavenger receptors, disrupted caveolin-1 localization in lipid raft plasma membrane microdomains, and activated phospho-ERK, phospho,AKT, and phospho -SRC in the testis, suggesting that class B opportunistic receptors are involved in cholesterol ester uptake for steroidogenesis and spermatogenesis in theTestis.

TL;DR: The fatty acid composition and the mRNA levels of key enzymes involved in fatty acid metabolism in testis of HSL-knockout mice were investigated and Mead acid, which has been associated with an essential fatty acid deficit leading to male infertility, was increased in the testis from H SL-knockingout mice.

TL;DR: The decrease in intracellular lipid deposition induced by curcumin is mediated by increased ceramide synthesis and exosome/microvesicle release, which may represent an additional health benefit ofCurcumin.