Rebeca Busto

TL;DR: It is found that miR‐21 is the most abundant miRNA in macrophages and its absence results in accelerated atherosclerosis, plaque necrosis, and vascular inflammation, and these findings reveal a major role for hematopoietic miR-21 in atherogenesis.

TL;DR: The effects of atypical or second-generation antipsychotics (SGA), such as clozapine, risperidone, and ziprasid one, on intracellular lipid metabolism in different cell lines are investigated, finding that these effects of SGAs on lipid homeostasis may be relevant in the metabolic side effects of antippsychotics, especially hypertriglyceridemia.

TL;DR: The results show that cholesterol is required for functional raft-dependent insulin signaling, and cholesterol repletion abrogated the effects of cholesterol biosynthesis inhibitors, reflecting they were specific.

TL;DR: In this paper, exosomes were isolated from raw bovine milk, combining ultracentrifugation and size exclusion chromatography (SEC) methodology, and then loaded with exogenous hsa-miR148a-3p, a highly expressed miRNA in milk exosome.

TL;DR: An analytical strategy combining high-performance liquid chromatography with evaporative light scattering detection and off-line coupling with matrix-assisted laser desorption/ionization with time-of-flight mass spectrometry to determine the composition of plasma and major lipoproteins at two levels, lipid classes and lipid species is developed.