M
Maria Helena Garcia
Researcher at University of Lisbon
Publications - 18
Citations - 312
Maria Helena Garcia is an academic researcher from University of Lisbon. The author has contributed to research in topics: Ruthenium & Cyclopentadienyl complex. The author has an hindex of 9, co-authored 17 publications receiving 272 citations. Previous affiliations of Maria Helena Garcia include Instituto Superior Técnico.
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Journal ArticleDOI
First polymer "ruthenium-cyclopentadienyl" complex as potential anticancer agent.
Andreia Valente,Maria Helena Garcia,Fernanda Marques,Yong Miao,Cyril Rousseau,Philippe Zinck +5 more
TL;DR: RuPMC was tested against human MCF7 and MDAMB231 breast and A2780 ovarian adenocarcinoma revealing IC50 values in the micromolar range, suggesting potential application of RuPMC as a new drug delivery system for Ru(II)Cp compounds.
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Oxidative electrochemistry of compounds of the type (.eta.5-C5H5)2MX2 where M = Ti(IV), Mo(IV), and W(IV) and X = halide, thiolate, or ferrocenyl
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Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds
TL;DR: Recent progress in work toward the development of new drugs based on Ru(II)- and Fe(II-cyclopentadienyl scaffolds is reviewed and the key role that coligands play in the overall behavior of the complex is reviewed.
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Cellular Uptake Mechanisms of an Antitumor Ruthenium Compound: The Endosomal/Lysosomal System as a Target for Anticancer Metal-Based Drugs
Leonor Côrte-Real,A. P. Alves de Matos,Irina Alho,Tânia S. Morais,Ana Isabel Tomaz,Maria Helena Garcia,Isabel Santos,Manuel Bicho,Fernanda Marques +8 more
TL;DR: Results obtained with two human tumor cell lines A2780 and MDAMB231 are presented on the compound distribution within the cell, the mechanism of its activity, and its cellular targets to elucidate the basis for the cytotoxic activity and mechanism of action of this RuII(η5-cyclopentadienyl) complex.
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May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents
Cristina P. Matos,Zelal Adiguzel,Yasemin Yildizhan,Buse Cevatemre,Tugba Bagci Onder,Ozge Cevik,Patrique Nunes,Liliana P. Ferreira,Maria Deus Carvalho,Débora L. Campos,Fernando Rogério Pavan,João Costa Pessoa,Maria Helena Garcia,Ana Isabel Tomaz,Isabel Correia,Ceyda Acilan +15 more
TL;DR: Initial studies show prospective anti-cancer and anti-MTb activity granting promise for further studies, including groove binding as the main interaction for most complexes with DNA, and for those containing amphen a B- to Z-DNA conformational change is proposed to occur.